"For some reason modern medicine has itself turned a corner and entered a darkness and is now committing crimes against humanity unequalled
in the history of our race."
 
--Dr. Mark Sircus
NATURAL HEALING 
featuring 
Alternative Cancer Treatments

INTRODUCTION: by DIANNE JACOBS THOMPSON (under construction)
1979 Around January of that year, I went home to die.   ..cont. 
I was diagnosed with stage 2 stomach cancer, chronic bronchitis, acutely infected ovarian cysts, arthritis, sciatica, low thyroid, anemia and a heart condition. Besides that I had chronic ear infections and long-standing clinical depression. The late Dr. Harold Dick, N.D., known as a "naturopathic oncology pioneer" cured me in 5 weeks. It required the diagnosis (the Carroll Food Test) of digestive enzyme deficiency food intolerances which most people have and few know about, and it also identified the primary tissue salt deficiency, along with treatment with glandular protomorphogens to restore glandular health, and Constitutional Hydrotherapy to bring about detoxification, to stimulate blood circulation and the activity of the vital organs and to jump-start the immune system. It turned out to be the basic foundation of the most successful healing system I've ever witnessed.
1986 My 5-year-old daughter was forcibly vaccinated and immediately developed a flesh-eating infection so virulent that my husband and I became infected from contact. Naturopathic medicine brought us back from the brink.
Later that year we were introduced to escharotic cancer salves and treated a dog tumor, my husband's cirrhosis of the liver, various skin lesions, moles, fungal infections, and a lump in my thigh. It eventually helped clear up the remaining symptoms from my husband's flesh-eating infection after he was forced to submit to antibiotic treatment which made a mess of it. There was much more, gallbladder problems in 1999, adrenal deficiency 2001, injury in 2002, arthritis, diabetes, and other issues between 2003-2012, including glaucoma--cured.

This is why I research and write about alternative medicine. It's a debt.

Please help support this website by purchasing hand-fired glass beads and jewelry at nitabeads1 to assist in covering the costs of books, reports, & articles needed for continuing research.


 

 

 

 


 


 

*Alternative treatments for cancer, chronic-degerative disease, infection, stress, harmful emotions and other disorders and conditions;
*Information about junk science and bad medicine, including unsafe and ineffective vaccines and undiagnosed medical conditions mimicking child abuse and Shaken Baby Syndrome;

Natural Healing Information
This site provides starting points. The rest of the journey must be yours.

"Truth wears no mask, seeks neither place nor applause, 
bows to no human shrine; she only asks a hearing"


SUBJECT: "CANCER SALVES", "BLOODROOT SALVES", "ESCHAROTIC SALVES", "BLACK SALVES" (DIFFERENT NAMES FOR THE SAME THING)

Photo Journal Pages 1  &  2 (Salve formulas below)
"Hoxsey: How Healing Becomes A Crime"

A "must-see" movie about the Hoxsey cancer protocol and medical persecution
"The quack that cured cancer"

from the book WHEN HEALING BECOMES A CRIME

"Unless we put medical freedom into the Constitution, the time will come when medicine will organize into an undercover dictatorship ...to restrict the art of healing to one class of men and deny equal privileges to others, will constitute the Bastille of medical science."
-- Benjamin Rush, M.D.
Signatory to the Declaration of Independence
Physician to George Washington

Reliable sources of cancer salves: http://www.altcancer.com/ (the links to their ordering sites are on this page, depending on where you live)  the most famous one--Cancema
http://cancerx.org/
http://www.blacksalveinfo.com/ -- http://bestonearthproducts.com/products.php?cat=8

Cancer Salves should not be a "stand-alone" treatment

First of all, CANCER SALVES--of which there are many more kinds than listed here--can remove tumors and cancer, even when metasticized, in most people (nothing is 100%) but removing cancer is only part of the job. You also need to change the internal environment that allowed the cancer to develop in the first place, which can involve altering one's mental state (stress reduction, negativity) and healing emotional trauma, grief, shock, anger (German New Medicine) as well as the physical body chemistry which responds both to mental states and environmental conditions. True healing involves a learning process as well as a treatment process. The best doctors I came across in the past knew nothing of salve treatment, but a great deal about the healing process from the inside out:

2008--The most successful healing PROGRAM I've personally ever seen or heard of evolved from a famous old naturopath, Dr. O. G. Carroll, ND, of Spokane, Washington, USA, who in turn had studied with one of the founders of American naturopathy and had been influenced by other masters. Those who came after him were our doctors--Drs. Leo Scott and Harold Dick, and Dr. Dick's students, Dr. Letitia Dick-Watrous and Dr. Jared Zeff, who are training the present generation using Dr. Carroll's innovative methods of diagnosis and treatment: the Carroll Food Test--a complex chemical analysis of digestive enzyme deficiencies most of us have without knowing it, which involves VOLL-related testing of the electro-magnetic reaction of blood to different foods or food combinations, the identification of primary mineral salt deficiency with the same test (unknown to conventional medicine), iridology and reflexology for further diagnostic work, the balancing of the endocrine system with glandular protomorphogens, careful use of herbal medicine combinations to help digestion, elimination, and congestion, Ayurvedic medicines and other supplements, specialized nutritional counseling which includes "7 raw foods per day" to provide the nutrients necessary to repair or replace diseased cells, and the other "big guns" in treatment: Constitutional Hydrotherapy, which is a combination of alternating heat and cold coupled with "electrotherapy" to stimulate blood circulation, digestion, waste removal and general immune function and vital organ activity, which normally triggers a spontaneous detoxification event for the elimination of stored-up poisons and waste products--the "sludge" that contributes to cell conversion to disease states, and/or the use of homeopathy and other medicines, and other treatments such as acupuncture (Dr. Zeff).

Overall, this program is a method of "getting the bad stuff out, putting good stuff in, and jump-starting the immune system to heal the body"--a protocol aimed at treating the patient, not the malady, with a focus on building up health rather than "attacking" disease. Health and disease do not co-exist. Build up one and the other declines.***DJT

Chosing the Best Treatment PRODUCT (to support the salve process) --How Do You Know What's Right For You?  http://alternativecancer.us The AlternativeCancer.US site has a VOLL testing kit with samples of several of the best-known cancer treatment products (some of which have not yet been added to the cancer treatment index page which is still under construction) that will indicate which products are most compatible with your body chemistry. It registers electro-magnetic responses to the test samples. To learn more about VOLL testing, that site has some information, and the following has more: http://www.pacifichealthcenter.com/updates/7.asp

Some of the following information involves complete healing protocols, and others are specific products. A "product" should be used in conjunction with a healing program which includes learning which foods and supplements are right for you, stress reduction, improving blood circulation and digestion, correcting endocrine (glandular) imbalances and mineral deficiencies with whole food products when possible (such as seawater at http://oceanplasma.com), raw, enzyme-rich foods, enzyme supplements--particularly pancreatic enzymes and digestive enzymes, and detoxification, both systemic and the liver in particular. Most cancers involve pancreatic enzyme deficiency and liver congestion and malfuction. Most people are toxic with environmental poisons, metabolic wastes, heavy metals, etc., have an acidic pH that needs to be alkalized, and are deficient in Omega 3 oils such as those from fish, which are the best source, or if these hard-to-digest oils won't metabolize properly, then substituted with something like flax or flaxseed oil blenderized with a high sulfur protein so it becomes water soluble (the Budwig protocol) although other seed oils can also be used in its place.

Bloodroot salve is not a gentle healer. There will most likely be pain and the necessity of "pain management" (drugs), scaring, and the need to do more than one application for aggressive, deep, and possibly metastasized cancers. There is no cancer treatment that is 100% effective on ALL people, but bloodroot has historically been far more effective that any form of conventional cancer treatment today. A medical facility, Dr. Nichols' Escharotic Salve Hospital, treated patients several decades ago and he gave patients an estimate of their recovery chances which ranged from "zero" to "100%". Salves were available in drugstores at the turn of the 20th century, and were known to be highly effective by American Indians and European settlers. In fact, "escharotics" were used by Hippocrates in ages long past.

However, the powerful pharmaceutical industry has taken unprecedented steps to destroy any and all natural healing protocols for cancer, forcing legislation to make it illegal for any medical doctor to use anything but conventional "cut, burn, and poison" methods to treat cancer. In fact, Medical doctors in the US have been threatened with the loss of their license and prison for even prescribing pain medication to adults who chose to use this type of treatment for cancer. People volunteering assistance in salve treatment have been threatened with arrest for "practicing medicine without a license". A mother was reportedly arresting for treating her teenaged son with salves and curing his "terminal" cancer.

One medical journal reported 4 cases of salve use that supposedly failed. And the alt med nemesis Quackwatch (now in disgrace legally) reported on 3 cases with devastating photos. Unfortunately, they didn't do their homework. Two of the cases were proven fraudulent, and the third photo probably was a salve case, but her picture was taken when the eschar (scab) first fell off leaving a hole in her nose, rather than after it healed up.

Photo Journal Pages 1  &  2
Family photos of salve use and anecdotal uses from other sources--more will be added later.

"BOTANICAL SURGERY"
Dr. Weil on Escharotic
Cancer Salves

From: SPONTANEOUS HEALING
pp. 48-50
(buy the book--it's very good)

 

Dr. Weil: describes getting a letter from a man in California, praising the ability of the herb bloodroot to dissolve moles and skin growths, and in one observed instance, a malignant melanoma. He urged Dr. Weil to order the salve from someone in Utah who made it up, and to experiment with it.

Dr. Weil did and got the container of oily red salve with no instructions. He did some research and found that it was a favorite of Indians and European settlers, but that it was now thought to be toxic taken internally, but he found "many references to its peculiar ability to dissolve abnormal growths on the skin without harming normal tissue, even to dissolving some breast cancers that eroded to the skin.." He thought it sounded safe to use externally.


cancerx.org TumorX salve and a cancer protocol including enzymes, minerals, and a treatment for cachexia, a CD for treatment advice, books and other materials.

Bloodroot cancer salve treatment has been "orthodox" medicine in the Philippines since 2002

TumorX Products are Avaliable World Wide
Jade Del Mundo Md. From the Department of Health invites you to the Philippines for your healing.

Philippine Department of Health

Excising news from the Philippine College For The Advancement In Medicine Foundation Inc. During their fourth annual meeting November 13-16, 2005 held at the Subic International Hotel, the Philippine Undersecretary of Health of the Office for Special Concerns, Dr. Jade F. Del Mundo M.D., F.P.B.O., F.P.C.S. ... announced that natural alternative cancer treatments like the TumorX Protocol are welcome to be practiced by qualified practitioners in the Philippines.

TumorX Paste has been used in the Philippines since 2002. The first patient who used the TumorX Paste was a lady with an ulcerated breast cancer, she had already used radiation and chemotherapy with no positive results at a local Manila hospital. Dr. Merced decided after reviewing her case, and consulting with peers in the Philippines and around the world, that her patient’s only hope of survival ... was to use an alternative protocol. Dr. Merced successfully use the TumorX Paste Protocol. After numerous applications of the paste the treatment was a complete success!

She, the patient is teaching at a prominent college in Manila thanks to the dedicated work of her doctor Fe Jocelyn G. Merced, M.D.

To see contact information and Biographer data on a potential Philippine Doctor click on their name. (go to the cancerx.org site for the actual links)

Dr. Carmencita R. Yap, M.D.
Dr. Merced, M.D.
Dr. Lemuel Tocjayao, M.D.

Research and Studies

Growing and Marketing Woodland Botanicals Jeanine M. Davis
http://www.hort.purdue.edu/newcrop/ncnu07/pdfs/davis274-279.pdf

Bloodroot (Sanguinaria canadensis L., Papaveraceae) is one of the first plants to emerge and bloom in the spring. It is a low growing plant with waxy lobed leaves and showy white flowers. The thick rhizome is dark on the outside, with a cream colored flesh and blood red sap (Fig. 4). The rhizome has traditionally been used as a dye, to treat skin lesions, and to prevent tooth decay (Persons and Davis 2005). The demand for bloodroot has been low but steady for many years, and as a result, it has been almost exclusively wild harvested. This changed dramatically when a German company began using it as an appetite stimulant in cattle feed. It is now also being studied for the treatment of cancer (e.g., Ahmad et al. 2000). The major alkaloid believed to be responsible for its medicinal and anti-microbial properties is sanquinarine (Leung and Foster 1996). Bloodroot studies are in progress on seed and vegetative propagation, tillage systems, and companion planting with other woodland botanicals (Persons and Davis 2005). Bloodroot is commonly propagated by rhizome cuttings and seed.

American Association For Cancer Research
http://clincancerres.aacrjournals.org/cgi/content/full/6/4/1524#ABS
Nihal Ahmad, Sanjay Gupta, Mirza M. Husain, Kaisa M. Heiskanen and Hasan Mukhtar2
Department of Dermatology [N. A., S. G., M. M. H., H. M.] and Department of Anatomy, School of Medicine [K. M. H.], Case Western Reserve University, Cleveland, Ohio 44106

ABSTRACT
Sanguinarine, derived from the root of Sanguinaria canadendid, has been shown to possess antimicrobial, anti-inflammatory, and antioxidant properties. Here we compared the antiproliferative and apoptotic potential of sanguinarine against human epidermoid carcinoma (A431) cells and normal human epidermal keratinocytes (NHEKs). Sanguinarine treatment was found to result in a dose-dependent decrease in the viability of A431 cells as well as NHEKs albeit at different levels because sanguinarine-mediated loss of viability occurred at lower doses and was much more pronounced in the A431 carcinoma cells than in the normal keratinocytes. DNA ladder assay demonstrated that compared to vehicle-treated control, sanguinarine treatment of A431 cells resulted in an induction of apoptosis at 1-, 2-, and 5-µM doses. Sanguinarine treatment did not result in the formation of a DNA ladder in NHEKs, even at the very high dose of 10 µM. The induction of apoptosis by sanguinarine was also evident by confocal microscopy after labeling the cells with annexin V. This method also identified necrotic cells, and sanguinarine treatment also resulted in the necrosis of A431 cells. The NHEKs showed exclusively necrotic staining at high doses (2 and 5 µM). We also explored the possibility of cell cycle perturbation by sanguinarine in A431 cells. The DNA cell cycle analysis revealed that sanguinarine treatment did not significantly affect the distribution of cells among the different phases of the cell cycle in A431 cells. We suggest that sanguinarine could be developed as an anticancer drug.

http://clincancerres.aacrjournals.org
3176 Vol. 9, 3176–3182, August 1, 2003 Clinical Cancer Research
Vaqar Mustafa Adhami, Moammir Hasan Aziz,
Hasan Mukhtar, and Nihal Ahmad2
Department of Dermatology, University of Wisconsin, Madison,
Wisconsin 53706
Activation of Prodeath Bcl-2 Family Proteins and Mitochondrial Apoptosis Pathway by Sanguinarine in iimmortalized Human HaCaT Keratinocytes1 (click link to go to article site)

http://www.cancerx.org/science_of_bloodroot.html
A summary of research findings
From escharotic salve expert Dan Raber's website:

"INTRODUCTION TO BLOODROOT"
Sanguinarine canadendid (bloodroot) is native to the moist woodlands of Eastern U.S. and Canada. This small North American herb is a member of the Papaveraceae Herbaceous perennial (poppy family), and possess attributes that are remarkable and almost unbelievable. Numerous doctors and researchers have investigated Sanguinarine canadendid, i.e., 13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium; the sap of the plant is bright red and is especially abundant with the alkaloid sanguinarine which is derived from rhizome (root system ), a benzophenanthridine alkaloid and a structural homologue of chelerythrine. Sanguinarine is known for its anti-cancer/anti-tumor, anti-inflammatory, anti-microbial (Sanguinarine broad in vitro activity against Gram-positive and Gram-negative bacteria, fungi, and some protozoa), anti-oxidant, and expectorant properties.

The effect of sanguinarine and its antiproliferative and apoptosis nature was investigated and the following found to be true:

1. Sanguinarine stops cancerous cells rapid growth.
2. Sanguinarine stops cancerous cells from abnormally increasing in number.
3. Sanguinarine stops the promotion of human epidermoid carcinoma cells, i.e., squamous cell (squamous cell is an invasive malignant tumor derived from epithelial tissue that tends to metastasize to other areas of the body).
4. Sanguinarine promotes the natural self-destruction (apoptosis) of cancer cells.
5. Sanguinarine will not promote apoptosis at any strength or concentration to health tissue.
6. Sanguinarine will promote necrosis (cell death ) in healthy epidermal keratinocytes (keratinocytes are the predominant cell type in the epidermis and dermis i.e. skin tissue) in concentrations above -10 µM (10-6 per unit).

Safety of Sanguinarine
The safety of sanguinarine has been demonstrated with over 400 years of use by professionals and novices alike. Sanguinaria extract, sanguinarine, has been used in many over-the-counter products, including toothpaste (the anti-inflammatory properties in human's to reduce gingival inflammation and supragingival plaque.), mouthwash, cough and cold remedies, and homeopathic preparations for cancer removal.

Sanguinaria Kills Squamous Cell Carcinoma
Sanguinarine treatment was found to result in a dose-dependent decrease in the viability of squamous cell carcinoma. Normally cancerous cells are unable to experience apoptosis by natural means. Sanguinarine (13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium) at 1-, 2-, and 5-µM doses was able to kill the cancerous tissue. DNA (deoxyribonucleic acid) ladder assay demonstrated that, compared to vehicle-treated control, sanguinarine treatment of squamous cell carcinoma resulted in an induction of programmed cell death as signaled by the nuclei in functioning cells. This process is characterized by cleavage of the DNA into fragments that give a so called laddering pattern then the solid phase of the cell liquefies.

The induction of apoptosis by sanguinarine was also especially clear when viewed with confocal microscopy (This microscope allows the observer to visualize objects in a single plane of focus, thereby creating a sharper image). This method identified the necrotic squamous cell carcinoma.

Sanguinaria Will Not Promote Necrosis To Healthy Skin Tissue
Sanguinarine treatment did not result in the formation of a DNA ladder or necrosis in normal human skin tissue. Necrosis did not occur even at the very high dose of 2 , 5, and 10 µM of sanguinarine. The results were viewed and verified with confocal microscopy.

The DNA cell cycle analysis showed that sanguinarine treatment did not significantly affect the distribution of cells among the different phases of the cell cycle in squamous cell carcinoma. (This is especially important because this proves definitely that sanguinarine will not affect the DNA of cells.) The researchers' work proves that sanguinarine is an effective natural anticancer chemical, and under normal circumstance sanguinarine will not promote damage to healthy tissue.

In fact, the safety of the product has been demonstrated with over 400 years of use by professionals and novices alike. Sanguinaria extract, sanguinarine, has been used in many over-the-counter products, including toothpaste (the anti-inflammatory properties in human's to reduce gingival inflammation and supragingival plaque.), mouthwash, cough and cold remedies, and homeopathic preparations for cancer removal.

The Search For Ancient Anticancer Chemicals Continues.
Agents that can eliminate the cancerous cells via a programmed cell death but do not affect the normal cells have a therapeutic advantage for the elimination of cancer cells.

Sanguinarine is a antiproliferative agent that has been developed as a anti-cancer agent as far back as 1600 A.D., by the peoples that inhabited North America which is currently the United States of America and Canada.

The Mechanism
Studies have shown that sanguinarine is a inhibitor of the activation of nuclear transcription factor NF-B, which has been implicated to play a key role in the regulation of cell growth, cell cycle regulation, and apoptosis. The anti-tumor properties of this alkaloid are constantly being reestablished.

At present, only a few agents are known to possess the potential for selective/preferential elimination of cancer cells without affecting the normal cells.

The University of Wisconsin studies provides more definitive evidence that sanguinarine at micromolar concentrations imparts a cell growth-inhibitory response in human squamous cell carcinoma and epidermoid carcinoma cells via an induction of apoptosis. In sharp contrast, normal human epidermal keratinocytes do not show any evidence of apoptosis, but undergo necrosis on treatment with higher concentrations of sanguinarine.
The University of Wisconsin research is the first study showing the complete cascade of events that lead to apoptotic cell death by sanguinarine. The University of Wisconsin researchers showed sanguinarine caused apoptosis of immortalized human Carcinoma tissue.

Chemistry Behind Sanguinarine's Apoptotic Cell Death
Normal keratinocytes is mediated via caspase activation triggered by modulations in Bcl-2 (B-cell lymphoma 2) family proteins-mediated cytochrome c release and the associated events. Bcl-2 is an anti-apoptotic gene. In fact, the link between apoptosis and cancer emerged when Bcl-2 , which is the gene that is linked to an immunoglobulin chromosome translocation pertaining to lymphoma, was found to inhibit cell death. This unexpected discovery gave birth to the concept that impaired apoptosis is a crucial step in the process of cancer development . In this study, The University of Wisconsin showed that sanguinarine treatment to the human Carcinoma tissue keratinocytes results in significant decrease in the levels of anti-apoptotic Bcl-2 protein and increases in the proapoptotic Bax protein. Thus shifting the Bax/Bcl-2 ratio in favor of apoptosis.

Studies have shown that Bcl-2 (i.e an enzyme that degrades DNA during apoptosis, inhibited by A molecule which represses or prevents another molecule from engaging in a reaction by the protein of 343 amino acids carrying a nuclear localization signal.) forms a heterodimer with Bax and might thereby neutralize its proapoptotic effects. In addition, Bcl-2 is also known to prevent the release of caspases. The University of Wisconsin studies have also shown the increase of protein levels of other proapoptotic members of Bcl-2 family, i.e., Bak and Bid, by sanguinarine treatment.

Furthermore, sanguinarine treatment of human Carcinoma tissue keratinocytes resulted in increase in the levels of cytochrome c (i.e. a protein which carries electrons that is central to the process of respiration in mitochondria (i.e. a small intracellular structurally discrete component of a cell which is responsible for energy production and the conversion within the cell of nutrients (such as protein molecules) into chemical energy in the form of ATP (adenosine triphosphate), by reacting the food with oxygen (O2) until the food has completely been degraded into carbon dioxide (CO2) and water (H2O.) and caspase.

These are important observations as it is known that the Bcl-2 family proteins (i.e. a proto-oncogene, activated by chromosome translocation in human B-cell lymphomas (hence bcl).. Encodes a plasma membrane protein. The gene product inhibits programmed cell death (apoptosis) and is homologous with the spiraling gene.) regulate the release of cytochrome c from the mitochondria into cytosol. Cytochrome c resides in the inter-membrane space of mitochondria, whereas its cofactors, Apaf-l and procaspase-9, are both cytosolic proteins. The over expression of Bcl-2 has been shown to block cytochrome c release in response to a variety of apoptotic stimuli. On the contrary, the pro-apoptotic members of Bcl-2 family proteins such as Bax, Bak, and Bid promote cytochrome c release from the mitochondria. The execution mechanism of apoptosis is mediated by caspases (cystein-yl aspartate-specific proteinases), which carry out the apoptotic program through a sequential activation cascade of initiator and executioner caspases. Apaf-1 induces activation of initiator caspase-9. Apaf-1 binds caspase-9 via the caspase recruitment domains at their NH2 termini, triggering the formation of a supramolecular complex. When activated, initiator caspase-9 triggers subsequent proteolytic activation of executioner caspase-3, caspase-7, and caspase-8. This whole process results in the cleavage of poly-adenosine diphosphate-ribose polymerase (i.e. an enzymes that catalyst the synthesis of nucleic acids on preexisting nucleic acid templates, assembling RNA from rib nucleotides or DNA from deoxyribonucleotides.) and subsequent DNA degradation and apoptotic death."

Contraindications
Contraindication from internally use: bloodroot should not be used if one is pregnancy, has high blood pressure, esophageal varicis, hiatus hernia, gastritis of peptic ulceration, and recent consumption of central nervous system stimulants. Use of emetics for more than three to four days can produce a serious medical condition if the assimilation of fluids is disrupted. This can lead to dehydration and severe electrolyte imbalances. Continual retching action from chronic emesis will strain the abdominal, gastric, and diaphragm muscles causing severe cramping and potential development of hernias.

Bloodroot used internally should not be administered to unconscious or deeply sedated individuals or in the event of convulsions, since bloodroot may cause aspiration of the gastric contents resulting in obstruction of the air passages.
Dan Raber

http://cancerres.aacrjournals.org/cgi/content/abstract/67/8/3888
Cancer Research 67, 3888-3897, April 15, 2007. doi: 10.1158/0008-5472.CAN-06-3764
© 2007 American Association for Cancer Research
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Sanguinarine-Dependent Induction of Apoptosis in Primary Effusion Lymphoma Cells

Azhar R. Hussain1, Naif A. Al-Jomah1, Abdul K. Siraj1, Pulicat Manogaran2, Khalid Al-Hussein2, Jehad Abubaker1, Leonidas C. Platanias3, Khawla S. Al-Kuraya1 and Shahab Uddin1

1 Human Cancer Genomic Research, King Fahad National Center for Children's Cancer and Research, 2 Biological and Medical Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia and 3 Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School, Chicago, Illinois

Requests for reprints: Shahab Uddin, King Faisal Specialist Hospital and Research Cancer, King Fahad National Center for Children's Cancer and Research, MBC#98-16, P.O. Box 3354, Riyadh 11211, Saudi Arabia. Phone: 966-1-205-5169; Fax: 966-1-205-5170; E-mail: Shahab@kfshrc.edu.sa.

Primary effusion lymphoma (PEL) is an incurable, aggressive B-cell malignancy that develops rapid resistance to conventional chemotherapy. In efforts to identify novel approaches to block proliferation of PEL cells, we found that sanguinarine, a natural compound isolated from the root plant Sanguinaria canadendid, inhibits cell proliferation and induces apoptosis in a dose-dependent manner in several PEL cell lines. Our data show that sanguinarine treatment of PEL cells results in up-regulation of death receptor 5 (DR5) expression via generation of reactive oxygen species (ROS) and causes activation of caspase-8 and truncation of Bid (tBid). Subsequently, tBid translocates to the mitochondria causing conformational changes in Bax, leading to loss of mitochondrial membrane potential and release of cytochrome c to the cytosol. Sanguinarine-induced release of cytochrome c results in activation of caspase-9 and caspase-3 and poly(ADP-ribose) polymerase (PARP) cleavage, leading to induction of caspase-dependent apoptosis. In addition, we show that pretreatment of PEL cells with carbobenzoxy-Val-Ala-Asp-fluoromethylketone, a universal inhibitor of caspases, abrogates caspase and PARP activation and prevents cell death induced by sanguinarine. Moreover, treatment of PEL cells with sanguinarine down-regulates expression of inhibitor of apoptosis proteins (IAP). Finally, N-acetylcysteine, an inhibitor of ROS, inhibits sanguinarine-induced generation of ROS, up-regulation of DR5, Bax conformational changes, activation of caspase-3, and down-regulation of IAPs. Taken together, our findings suggest that sanguinarine is a potent inducer of apoptosis of PEL cells via up-regulation of DR5 and raise the possibility that this agent may be of value in the development of novel therapeutic approaches for the treatment of PEL. [Cancer Res 2007;67(8):3888–97]

[Cancer Research 66, 3726-3736, April 1, 2006]
© 2006 American Association for Cancer Research
Cell, Tumor, and Stem Cell Biology
Cyclooxygenase 2 Rescues LNCaP Prostate Cancer Cells from Sanguinarine-Induced
Apoptosis by a Mechanism Involving Inhibition of Nitric Oxide Synthase Activity

Jacob Huh1, Andrejs Liepins1,{dagger}, Jacek Zielonka2, Christopher Andrekopoulos2, Balaraman Kalyanaraman2 and Andrey Sorokin1

Departments of 1 Medicine and 2 Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin

Requests for reprints: Andrey Sorokin, Department of Medicine, Medical College of Wisconsin, CVRC, 8701 Watertown Plank Road, Milwaukee, WI 53266. Phone: 414-456-4438; Fax: 414-456-6515; E-mail: sorokin@mcw.edu.

Expression of cyclooxygenase-2 (Cox-2), an inducible enzyme responsible for the production of prostaglandins from arachidonic acid, is elevated in human prostate tumor samples. The aim of this study was to investigate whether expression of Cox-2 is effective against prostate cancer cell apoptosis triggered by sanguinarine, the quaternary benzophenanthridine alkaloid with antineoplastic properties. Sanguinarine effectively induced apoptosis in LNCaP human prostate cancer epithelial cells as assessed by caspase-3 activation assay, Annexin V staining assay, or by visual analysis for the apoptotic morphology changes. Sanguinarine-mediated apoptosis was associated with the increase of nitric oxide (NO) formation in prostate cancer cells as assessed by measurements of nitrites with Sievers nitric oxide analyzer as well as flow cytometry analysis using NO fluorescent sensor. Activation of NO synthase (NOS) activity was crucial for sanguinarine-induced cell death because NOS inhibitor L-NMMA efficiently protected cells from apoptosis. Adenovirus-mediated transfer of Cox-2 into LNCaP cells inhibited sanguinarine-induced apoptosis and prevented an increase in NO production. Surprisingly, NO donors failed to induce apoptosis in LNCaP cells, suggesting that constitutive NO generation is not sufficient for triggering apoptosis in these cells. Besides NO generation, NOS is also capable of producing superoxide radicals. Sanguinarine-induced production of superoxide radicals, and the addition of MnTBAP, a scavenger of superoxide radicals, efficiently inhibited sanguinarine-mediated apoptosis. These results suggest that Cox-2 expression rescues prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of NOS activity, and that coadministration of Cox-2 inhibitors with sanguinarine may be developed as a strategy for the management of prostate cancer. (Cancer Res 2006; 66(7): 3726-36)

Originally published In Press as doi:10.1074/jbc.M501467200 on March 7, 2005
J. Biol. Chem., Vol. 280, Issue 19, 19078-19086, May 13, 2005
The Benzo[c]phenanthridine Alkaloid, Sanguinarine, Is a Selective, Cell-active Inhibitor of Mitogen-activated Protein Kinase Phosphatase-1*
Andreas Vogt{ddagger}, Aletheia Tamewitz, John Skoko, Rachel P. Sikorski, Kenneth A. Giuliano§, and John S. Lazo
From the Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261

Mitogen-activated protein kinase phosphatase-1 (MKP-1) is a dual specificity phosphatase that is overexpressed in many human tumors and can protect cells from apoptosis caused by DNA-damaging agents or cellular stress. Small molecule inhibitors of MKP-1 have not been reported, in part because of the lack of structural guidance for inhibitor design and definitive assays for MKP-1 inhibition in intact cells. Herein we have exploited a high content chemical complementation assay to analyze a diverse collection of pure natural products for cellular MKP-1 inhibition. Using two-dimensional Kolmogorov-Smirnov statistics, we identified sanguinarine, a plant alkaloid with known antibiotic and antitumor activity but no primary cellular target, as a potent and selective inhibitor of MKP-1. Sanguinarine inhibited cellular MKP-1 with an IC50 of 10 µM and showed selectivity for MKP-1 over MKP-3. Sanguinarine also inhibited MKP-1 and the MKP-1 like phosphatase, MKP-L, in vitro with IC50 values of 17.3 and 12.5 µM, respectively, and showed 5–10-fold selectivity for MKP-3 and MKP-1 over VH-1-related phosphatase, Cdc25B2, or protein-tyrosine phosphatase 1B. In a human tumor cell line with high MKP-1 levels, sanguinarine caused enhanced ERK and JNK/SAPK phosphorylation. A close congener of sanguinarine, chelerythrine, also inhibited MKP-1 in vitro and in whole cells, and activated ERK and JNK/SAPK. In contrast, sanguinarine analogs lacking the benzophenanthridine scaffold did not inhibit MKP-1 in vitro or in cells nor did they cause ERK or JNK/SAPK phosphorylation. These data illustrate the utility of a chemical complementation assay linked with multiparameter high content cellular screening.

Received for publication, February 8, 2005

* This work was supported by National Institutes of Health Grants CA78039 and CA52995 and the Fiske Drug Discovery Fund. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

§ Current address: Cellumen, Inc., 100 Technology Dr., Pittsburgh, PA 15219.

{ddagger} To whom correspondence may be addressed: Dept. of Pharmacology, The Hillman Cancer Center G.27a, University of Pittsburgh, Pittsburgh, PA 15213. Tel.: 412-623-1216; Fax: 412-623-1212; E-mail: avogt@pitt.edu.
To whom correspondence may be addressed: Dept. of Pharmacology, Biomedical Science Tower E-1340, University of Pittsburgh, Pittsburgh, PA 15261. Tel.: 412-648-9319; Fax: 412-648-2229; E-mail: lazo@pitt.edu.

http://www.cancerx.org/pancreatic_cancer_cure.html
A Cure of Pancreatic Cancer?
Diagnosed pancreatic cancer will touch the lives of an estimated 33,730 persons in 2006; in the same year 32,300 deaths will occur, 3 based on current pancreatic cancer health trends… to put this into context 2.26 persons per 100 should survive after 5 years using allopathic treatments. This statistic demands that allopathic treatments be re-examined, when the best they offer is a 98 percent death rate.

Technically Speaking
When using Sanguinarine the mitochondria is the target for the destruction of cancer. 4 Studies showing the modulation of mitochondrial events and the process of apoptosis by bloodroot are useful in phytochemicals prevention as well as phytochemicals therapy of cancer and possibly other
hyper proliferative disorders .Pancreatic cancer AsPC-1 and BxPC-3 cells studied at the University of Wisconsin, demonstrated that sanguinarine (bloodroot) treatment to AsPC-1and BxPC-3 cells resulted in a dose dependent inhibition of cell growth (up to 62% in AsPC-1 and 47.3% in BxPC-3 cells at 10 µM)inhibition of cell viability up to 97.3% in

AsPC-1and 95.6% in BxPC-3 cells at 10 µM arrest of cells in G0-G1 phase of the cell cycle up to 64.7% in AsPC-1 and 74.1% in BxPC-3 cells at 10 µM induction of apoptosis 97.9% in AsPC-1 and 96.5% in BxPC-3 cells at 10 µM.

Please note the bloodroot extract was present for 24 hours before testing. 4

1.http://www.cancer.org/.......
2. 2006 American cancer Society, Inc No. 500606
3. http://www.cancer.gov/.......
4. Experimental and Molecular Therapeutics Novel Agents 1 Abstract #629

Prostate Cancer e-mail: FlowWOOLF@swbell.net for products

* Prostate Cancer Prevalence: Prostate cancer is the second most common cancer in the U.S.; it is the second leading cause of cancer-related death to American men. In 2002, an approximate 189,000 men were diagnosed with, and 30,200 men died from this disease. African American men are more likely than other racial and ethnic populations both to develop and to die from PC. (footnote 9). Scientific evidence suggests that about one-third of PC could have been averted with proper nutrition, (footnote 2) e.g., foods rich in antioxidants and immune stimulating substances such as co-enzyme Q10. Historical and emerging research also shows that supplementing with herbs that have been proven to change the structure/function of PC cells can be the key to managing this disease. (footnote 3-5, 11)

* Studies: In a study, Sanguinarine was tested for the management of PC. Mice were implanted with human PC tumors. The study demonstrated the preventive and post therapeutic effects of sanguinarine against PC. (footnote 10) A study from the Czech Republic analyzed sanguinarine and proved that sanguinarine is an excellent herb which can deliver therapeutic results to men burdened with PC. Sanguinarine enhances the immune system by means of utterly destroying cancer cells. (footnote 11)

* The Science of Curing Prostate Cancer: Sanguinarine destroys cancer cells. (footnote 3-5, 7-11) Sanguinarine has been shown to cause cell cycle blockade and apoptosis of human prostate cancer cells irrespective of their androgen status. This is an important finding, because prostate cancer is known to undergo a transition from an early “androgen-sensitive” form of cancer to a late (metastatic) “androgen-insensitive” form of cancer. At diagnosis, most prostate cancer represents a mixture of androgen-sensitive and androgen-insensitive cells. Therefore, the key to the control of prostate cancer seems to lie in the elimination of both types of prostate cancer cells (without affecting the normal cells) via mechanism-based preventive/therapeutic approaches. (footnotes 3-5) Overall, the results of studies indicate that sanguinarine is a useful agent in the destruction of PC.

* Conclusion: Persons with cancer should take a multi-function approach to repairing their body.

First,
by using Pancreatic Enzyme Therapy, TumorXTM Formulas (103X, 303X, & 403X), to destroy cancer cells.6

Second,
by using Formulas ApoptosisTM Full Strength, & Easy Digest, which contain the life saving phyto-nutrient sanguinarine which has been proven to destroy cancer cells.(footnotes 3-5)

Third,
by the addition of Formula Pure Energy ATPTM
(footnote 7) which allows the body to convert the poisonous waste of cancer into energy.

And fourth, by using BioEnerGetics Q-10,TM 8 an antioxidant scavenger which stimulates the immune system.

Resources

1. http://www.cdc.gov/cancer/prostate/decisionguide/index.htm

2. 2006 American cancer Society, Inc No. 500606

3. Mol Cancer Ther. 2004;3:933-940

4. Proc Amer Assoc Cancer Res, Volume 46, 2005

5. Cancer Res 2006; 66: (7). April 1, 2006

6. Pancreas. 28(4):401-412, May 2004.

7. Journal of the National Cancer Institute, Vol. 92, No. 4, February 16, 2000

8. National Cancer Institute Questions and Answers About Coenzyme Q10

9. Prostate Cancer Progress Report 2004 National Cancer Institute of Health

10. Sanguinarine: A Novel Agent Against Prostate Cancer. - Annual rept. 16 Jan 2004-15 Jan 2005.

11. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006, 150(1) 5–12.

12. DOD award number W81XWH-04-100220 TITLE: Sanguinarine: A Novel Agent Against Prostate Cancer

Bloodroot Information:
http://www.med.unc.edu/phyrehab/ncmedicinalherbs/Bloodroot/Bloodroot-cg.pdfProgram on Integrative Medicine, Department of Physical Medicine and Rehabilitation,
School of Medicine, University of North Carolina, Chapel Hill, NC 27599-7200. http://pim.med.unc.edu/
Prepared by Faurot KR, Kroll DJ, Curtis P, Greenfield JT, Siegel SY, Gaylord SA, Mann JD
For the NC Consortium on Natural Medicines-funded by a grant from the GoldenLEAF Foundation

A monograph using the following references:

1. Adhami VM, Aziz MH, Mukhtar H, Ahmad N. Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes. Clin Cancer Res 9 (8): 3176-82, 2003.
2. Alleger I. Cancer Salves: A Botanical Approach to Treatment. Townsend Letter for Doctors & Patients: Townsend Letter Group, pp. 142, 1999.
3. Brinker F. Herb contraindications and drug interactions. Second ed. Sandy, Oregon: Eclectic Medical Publications, 1998.
4. Clark P. Scientists hope bloodroot plant could be new crop for farmers. Vol. 2004: Asheville Citizen-Times, 2002.
5. D'Adamo P. Chelidonium and Sanguinaria alkaloids as anti-HIV therapy.
Journal of Naturopathic Medicine. Vol. 3: American Association of Naturopathic Physicians, pp. 31, 1992.
6. Davis J, Greenfield J. Results from Strategic Reports' Analysis of the economic viability of cultivating selected botanicals in North Carolina, 2001 statistics. Raleigh, NC: North Carolina State University, pp. 243, 2003.
7. Duke JA. The Green Pharmacy. Emmaus, Pennsylvania: Rodale Press, 1997.
8. Eley BM. Antibacterial agents in the control of supragingival plaque--a review.
Br Dent J 186 (6): 286-96, 1999.
9. Foster S, Duke J. A Field guide to Medicinal Plants and Herbs of Eastern and Central North America. New York: Houghton Mifflin, 2000.
10. Grieve M. A Modern Herbal. New York: Dover Publications, Inc, 1971.
11. Hoffman D. Medical Herbalism. Rochester, Vermont: Healing Arts Press, 2003.
12. Hutchens AR. Indian Herbology of North America. Boston: Shambhala Publications, Inc., 1991.
13. Jellin JM, Gregory PJ, Batz F, Hitchens K. Pharmacist's Letter/ Prescriber's Letter Natural Medicines Comprehensive Database. Vol. 2004. Stockton, CA: Therapeutic Research Faculty, 2004.
14. Lust J. The Herb Book. New York: Bantam Books, 1974.
15. Mascarenhas AK, Allen CM, Moeschberger ML. The association between Viadent use and oral leukoplakia--results of a matched case-control study. J Public Health Dent 62 (3): 158-62, 2002.
16. McDaniel S, Goldman GD. Consequences of using escharotic agents as primary treatment for nonmelanoma skin cancer. Arch Dermatol 138 (12): 1593-6, 2002.
17. Mills S, Bone K. Principles and Practice of Phytotherapy. Philadelphia: Churchill Livingstone, 2000.
18. Simard F, Landry RG. Mouthrinses as an antibacterial adjunct in periodontal treatment.
J Can Dent Assoc 60 (10): 906-7, 910-1, 1994.
19. Sturdivant L, Blakeley T. The Bootstrap Guide to Medicinal Herbs in the Garden, Field, & Marketplace. Friday Harbor, WA: San Juan Naturals, 1999.
20. Tenenbaum H, Dahan M, Soell M. Effectiveness of a sanguinarine regimen after scaling and root planing. J Periodontol 70 (3): 307-11, 1999.
21. Thornton L. Wildcrafters Alert! Aromatic News: Herbal Rose Report, pp. 4A, 1999.
22. Tierra M. The Way of Herbs. New York: Pocket Books, 1998.


Anyone considering using salves, please purchase the book "Cancer Salves" by world-renowned expert Ingrid Naiman, the definitive book on salves which is available through her website http://cancersalves.com and most online bookstores, sometimes in used paperback copies. The book contains formulas for most if not all salves and instructions for use. The formula and instructions on this page may not be right for all. In fact, unless the cancer is unusually aggressive, she prefers other types of salve with herbs other than bloodrood and some without zink chloride, which helps to penetrate into the tissues deeper to pursue internal cancers and metastatic spread. With more information, people are better able to make good choices. Even though the photos show an application on a leg, the instructions here are for a general location to check for internal cancer or abnormal tissues, or to treat a condition in the area of the organs, but a cancer on the skin or closer to the surface is usually done at that location and the application of the salve may be very small or best used covering the entire area of a skin cancer. Also, the cancerx.org site has an instruction booklet and CDs, besides an excellent escharotic salve and treatment program with very important enzyme and mineral supplements. The enzymes alone fight cancer. They also have a very specific supplement to treat "cachexia" --the condition where the body consumes itself because it can't metabolize proteins and it results in a kind of starvation and emaciation.

 


Below: A review from the Eclectic Medicine International (EMI) staff at
http://www.holisticcancersolutions.com/

(
(A paid membership site--an excellent source of information on little-known treatments)

"Escharotic salves and pastes represent a botanical approach to cancer treatment. They are mostly applied topically, but can also be taken internally.

The efficacy of a well-prepared cancer salve is 100%. This doesn't mean that it is the appropriate treatment for all cancers, but when applied, it always works.

What is this medication, and what does it do?

The cancer salve is a paste, made of native American herbs, that is placed on a small spot on the skin, close to a diagnosed or suspected malignancy. The salve will cause the skin to react, but if there is no malignancy, nothing will happen. However, if there is a tumor present within the tissue under the selected spot, the salve forces the body to eject the tumor by bringing it to the surface, until it completely emerges and detaches itself from the skin. The process usually begins by pus-like fluid oozing through the lesion, then within 2-3 weeks the main tumor will emerge, without the need for any interference, and with no danger of metastasis. In some cases the tumor doesn't come out as a solid object, but as thick fluid, or, in the case of prostate cancer, for instance, as a number of small, jelly-like globules. Should the cancer be melanoma, or another type of skin cancer, the salve will eliminate the condition through topical action.

Escharotics, as a cancer treatment, have a long history in North American medicine. Even as recently as during the past two decades, thousands of people used this method to get rid of their cancers. We managed to talk to dozens of women who treated themselves with breast cancer, or were helped by an expert in using the salve. One of them is an MD who brought out a tumor from her breast by this method. We were able to find only two NDs on the whole continent who have experience with the salve, and can be consulted on its use. One of them recently published a very well written and instructive book on the subject.

For someone to whom escharotic treatment is a completely alien concept, it is difficult to accept that breast cancer can be taken care of within a few weeks, at a cost of less than $100. Of course, if the tumor is very large, or there are other complications, the treatment must be prepared very carefully. It is always important for the person undergoing such treatment to place him/herself under the guidance of a holistic physician who understands the whole procedure. Otherwise the patient may panic as the site opens up. At that stage, running to an oncologist or a doctor who has no idea of what is happening will likely result in totally unnecessary and dangerous surgical intervention. The emerging matter must be kept sterile until it is ready to completely detach itself from the skin. The process may cause some discomfort, mainly an itching or burning sensation that can be controlled by the use of Aqua Argentica, a special Canadian colloidal silver product, sprayed regularly on the site.

We strongly encourage alternative doctors to participate in seminars where this remarkable cancer treatment would be explained to them. It cannot be emphasized enough how important it is to consult with as many advisors as possible on this matter. There are experts who bring out deep, inoperable tumors from the most unlikely locations within the body by applying the salve topically. It is obvious that this whole field is unexplored, and it is vitally important to build a data bank and share it with everybody. EMI will assist those who are interested in forming a group and attending a workshop with one of the experts. Please keep in mind that almost any cancer, even if sometimes as a last resort, can be treated in this manner. This is not to say that the salve should be regarded as a mono-therapy. It should always be part of an integrated protocol. Having said that, let us state in no uncertain terms: When a woman is diagnosed with a tumor in her breast, before any surgical intervention, even before a biopsy, an expert should be contacted and a treatment with escharotics should be discussed. Chances are that the cancer can be eliminated without danger, at a very modest cost. Inoperable brain tumors were drained through a lesion on the neck with this method, and lung cancer has been successfully treated with the salve. All these positive results do not mean that this therapy is without risk. No one should enter self treatment recklessly, without the supervision of a knowledgeable practitioner.

Although completely unknown by virtually all physicians, escharotics has a century-old history of medical use. Like so many other natural modalities, it has been suppressed and totally eradicated from standard medical practice. It is one of the greatest tragedies of current medical policy that women, who should have no more difficulty getting rid of a newly diagnosed breast cancer than of a flu or the common cold, are subjected to mutilation, and are dying by the thousands from this condition.

At this point the question can be raised, and not without justification: is this whole presentation some elaborate scam? Is it possible that such a dread disease like breast cancer, that claims the lives of hundreds of thousands of women, can be eliminated with a ridiculously simple and cheap method? If this is true, where are the headlines? The announcements? Even the Nobel prize?

Well, on this Website (http://www.holisticcancersolutions.com/) we don't discuss political and philosophical issues. Our task is to present solutions, and make these solutions accessible to our readers. Keep in mind that although the cancer salve may appear a little more bizarre than some other treatments, it is not an exception where complete blackout of its efficacy is concerned. Like many other treatment modalities that completely disappeared from the practice of orthodox medicine, the cancer salve, too, was well known among physicians in England and North America."


http://www.planetherbs.com/articles/thoughts_on_the_use_of_escharoti.htm

Dr. Michael Tierra L.AC., O.M.D.

Founder of the American Herbalists Guild,
author of numerous books on health and herbal healing including:

The Way of Herbs
, The Natural Remedy Bible and The Way of Chinese Herbs, (Pocket Books),
Planetary Herbology, Chinese Traditional Herbal Medicine, Vol. 1 & 2
Biomagnetic and Herbal Therapy (Lotus Press) and The East West Course of Herbology.

Thoughts on the Use of Escharotic Pastes for the Treatment of Cancer
August 30, 2005 --Michael Tierra

While I tend to agree that local surgery and cauterization of basal cell carcinomas (BCC) is often preferable to the use of escharotic salves, this is especially true because of obvious liability issues to anyone involved with the process --- thus practicing in Mexico as Jonathan suggests may be a wiser option (providing someone wants to live there).

Due to the generosity of Ingrid Naiman, I have a copy of the medical text, Chemosurgery by Frederic Mohs M.D., edition 1978. I also read in detail the citation offered by Paul Bergner, http://naimh.com/x/web-3/escharotics.pdf , as criticism of the use of escharotic agents. I have also interviewed a number of people including a primary source individual (Clark Bigham) who was financially involved with funding Vipont Pharmaceutical Company, located in Fort Collins, Colorado sometime in the 1960's. The company was specifically formed to research and bring to market a "Black Salve" consisting of sanguinarea, galangal and zinc chloride mixed with distilled water. The salve was and still is widely used in veterinary medicine throughout the Wyoming and Colorado areas. It was, and probably still is, used by individuals on local external cancers. It so happens that Clark lives in Santa Cruz and was a former student of mine. He said he was introduced to the salve by Howard McCreary a 'cowboy' in the region. Together with Howard's investment, they formed Vipont Pharmaceuticals. Their research went as far as their money. They also have a letter from Sloan Kettering, who after their research, stated that their salve was the most effective substance against cancer they had ever seen. They found that a diluted version (5%) of the salve is 100% effective as diluted eye drops for macular degeneration and one type of glaucoma. Because when mixed with toothpaste at a 5% ratio with Tom's toothpaste, it cures gingivitis, it was bought out by Colgate-Palmolive and is presently sold as Viadent toothpaste.

Clark's personal formula uses up to 50% zinc Chloride, to the remainder would obviously be bloodroot and galangal. He will dilute it (5 to 10%) for various uses, especially cosmetic uses and uses it straight on moles, warts and such. In over 28 years, he has never seen an adverse reaction.

The term anecdote (suggesting that something is unproven) is thrown around so that I think its meaning is often stretched. By definition, one can offer both 'anecdotal' positive as well as 'anecdotal' negative because neither is proven. There's a question and to what degree evidence becomes non-anecdotal. To my way of thinking to say that something is effective based on personal observation, meaning not confirmed by others, is anecdotal, but isn't saying that something is inefective based on personal observation also anecdotal (non confirmed)? Then who, how, under what circumstances and how many people need to witness evidence before it becomes non-anecdotal?

I say that the escharotics deserve and are in need of more debate and scientific research. I suspect that there are problems on all sides of the issue.

In terms of their proponents, I question the escharotic power of dried bloodroot. I think the exudate, along with the exudates of celandine and the fresh oils of garlic are mildly escharotic, but the dried root, for some reason I've never just added water and topically applied it to see if it is. I've used the tincture topically for the treatment of skin funguses and again think that the fresh herb tincture would be best.

So few people who are proponents of escharotics talk about the properties and importance of a 'major' active in the formulation, zinc chloride.

In criticism of Mohs (directly reading his book) first published in 1958, gives absolutely no credence or acknowledgement to over a century of use of what is essentially the same paste used by Felter and the Eclectics nearly 60 years previous. He also gives no acknowledgement of Harry Hoxsey's use of essentially the same paste for decades previous up into the 1950's. It is a glaring fact and in my opinion an obvious prejudice among the medical community that Mohs misrepresented on page 3 how he 'happened' to come upon his 'chemosurgery' formula.

He does acknowledge that zinc chloride was found as early as the 19th century to be the most "satisfactory" chemical for the paste because it produced the least toxicity and "did not impair the reactivity or healing quality of the tissues beyond the deepest level of fixation."

So right off, we have the proponents of the folk application who tacitly seem to deny that the basis of their 'natural' therapy is herbal (based on the use of bloodroot) when a pure chemical zinc chloride is at least responsible for 50% of the activity of the formulation. On the other side, we have Mohs, developing what to this day is regarded as an effective external anti-cancer therapy (we're not talking about minor excrescences and spots on the skin, but large major areas of the eroded cancerous flesh, eye, breast, genitals, back, etc..) and thousands of cases that he, Mohs, personally treated with his method, while giving absolutely no acknowledgment, which I can only conclude is because of political reasons to the popular use of essentially the same paste.

Now the above reference paper submitted by Paul Bergner is written by dermatologists at the Vermont College of Medicine in Burlington. There are some problems with this paper which to my mind make it even more suspect and biased against the popular use of the paste and its value.

1. They claim to review the history of escharotics for skin disease and based on Mohs use alone, they claim that the use of "escharotics without surgery has been discredited by allopathic medicine" --- this is at the top of the article and there is no reference. Their conclusion is for the FDA to be given authority to regulate the production and distribution of escharotics and by implication other herbal preparations. --- so there is an agenda here.

Later, despite Mohs' use of essentially the same paste, these same individuals claim that "Hoxsey's work has never been accepted as valid (not mentioned is that despite a will to prove otherwise, it has also never been proven to be 'invalid'). The claim that Mohs' method is different only in the fact that it included surgery.

This last point is something to consider. I find that scientific manuals such as Mohs are generally poorly written (i.e. failing to impart the highest level of clarity) either deliberately or what is more disgusting to disguise certain elements that they specifically do not want the reader to know.

So the research paper states that Mohs only used the salve as part of a "fixed tissue technique" as if everyone reading would understand what this means. Mohs, in his first chapter, does not help to define what he means by "fixation in situ" so I'll venture a surmise that the application of the salve seems to destroy or "fixate" primarily Cancerous lesions, and "did not readily penetrate the keratin layer of the skin." This being the thicker, more impenetrable areas of the skin (similar to the soles of the feet). So healthier skin tissue seems to be more resistant to the topical application of zinc chloride --- this seems to substantiate to some degree the claims of those who popularly use the salve. In fact, Mohs would have to specifically apply a keratolytic chemical, namely dichloracetic acid first in some cases to allow the zinc chloride paste to penetrate. Then, on page 4, Mohs says the most pertinent thing "zinc chloride (with sanguinarea added) did not impair the reactivity or healing qualities of the tissues just beyond the deepest level of fixation. To this property was credited not only the rapid separation of the final layer of fixed tissue, but also the healthy infection-resistant granulation tissues, the rapid epithelization and the minimal scarring that resulted from its use. This lack of damage to surrounding tissues by zinc chloride (my own inclusion is -- including sanguinarea) contrasted with the effect of cauterization of tissues by heat which could cause thermal damage to tissues just beyond the deepest level of actual cauterization."

So it seems that Mohs is opting for a chemical burn as opposed to an actual thermal or radiation burn because the chemical burn is more selective specifically to unhealthy cancer cells and causes far less damage to healthy tissue. ---- again this is what is being claimed as a benefit by popular or folk protagonists who use the salve.

Another distinction is that Mohs used surgery. Except for the obvious benefit in first debriding a large tumor before applying the paste. It's not clear why else he needed to use it, except that perhaps he simply did not want to wait out the couple of weeks before a complete and distinct eschar would form and by itself, slough off. Consider this, he already admits that the paste fixates the cancerous area of a lesion, that it does not penetrate non-cancerous tissue (which is why he uses zinc chloride over other possible chemicals) and this is based on Mohs' personal treatment and observation of thousands of patients, but after the cancerous lesion is affected and begins to isolate, Mohs cuts it away. He then microscopically examines the area and if continues to apply the paste followed by surgery until there are no signs of cancer.

So the difference between the popular recommendation of the salve is they claim that once the eschar is formed, it should be allowed to run to completion and slough off on its own and this optimizes the complete excision of cancer from the site. Here criticism may well be in order, because experience seems to demonstrate that not always is the cancer completely removed after the initial eschar is sloughed off and so amid the success stories with the use of escharotics, there are the negatives of cancer recurrence that are also reported (how many times is this true after conventional chemo or radiation therapy?). Here it seems to be would be a good place for cooperation between the two camps. Selective microscopic analysis and biopsy of the area after the eschar sloughs off, seems a most appropriate use of that technology and would make the entire procedure exponentially that much more effective.

The issue of pain: In the past I have assisted a few with escharotics and I might add, without witnessing particularly dazzling results, although I confess that this may well be because of my tendency to err on the side of being conservative. Nor will I sell the paste to anyone who requests it. Healing is a potentially risky business and different ones of us must choose their own personal level of risk and my own would not allow me to go the distance. However regarding pain, I have much knowledge because after applying the paste, pain is to a greater or lesser extent a reality sometime over the course of the first three days. It is very idiosyncratic, for some it is a minor thing somewhat more than an irritation, for others it is excruciating to the point that no herbal pain killers, unless we could be permitted to use our opiates, would be effective. Aspirin and Tylenol, to opiates are a welcome part of therapy. After the initial few days, presumably when the nerve endings have desensitized, pain killers are no longer necessary.

Scaring and mutilation: Before damning escharotics as being scaring and mutilating please consider the effect of other heroic measures such as surgery, chemotherapy and radiation. Cancer is a serious disease and its treatment whether conventional or so-called natural is serious and not without consequences. Let's assume, again without the research that I would really like to see, that there are cases where the cancer cells extend beyond expected areas and the salves cause massive disfigurement and scaring. Or even that on some individuals the keratinized areas of the skin or deeper tissues are susceptible to damage by the salve (although most claim it is not and I have never seen it to be), there will be a need for reconstructive surgery for some. Again, one only chooses this technique not because it is risk free, but because it offers the best possible outcome over any other method considered. That is the price that one pays. Some who undergo it, either ill advised or with misleading expectations, understandably may be seriously upset with the outcome, this happens all the time in conventional treatment of cancer, so why should it not be a reality in so-called alternative medicine.

The real question is should the potential benefits of escharotic treatment for a wide variety of cancers be not one of the choices a patient can opt for in deciding their best course? If conventional medicine does not make this available and continues to ignore and deny research to an area that even one of their most respected members gave credence to, I believe that escharotic pastes will continue to be available on a 'buyer beware' basis. Our right and freedom to choose, hopefully based on informed understanding, is what is at stake and I don't believe that freedom should legislatively denied. Does this sound a bit familiar regarding other issues of the day?

Michael Tierra


BLOODROOT SALVE WEBSITES
Native Black Salve --A formula without the zink chloride, from a site that also sells a cream to help prevent scarring.
http://plantcures.com/herbsforcancer.html Bloodroot tincture for internal use/can be made into a salve, and immune system stimulants --restore health, don't just remove cancer

http://www.blacksalveinfo.com/

http://www.cancersalves.com

http://www.altcancer.com --home of the most famous salve, CANSEMA, and the most experienced salve professionals--read the entire site. The following link is just one of their more dramatic cases.

http://www.altcancer.com/rlbanks.htm

http://www.leishmaniasis-treatment.info/cerro_azul/jose.htm

http://www.annieappleseedproject.org/balofgilblac.html

http://sunwatt.mystarband.net/canceroptions.htm

http://www.diamondjdonkeys.com/Sassie.htm

http://sunwatt.mystarband.net/cansema_salve.htm

http://www.mnwelldir.org/docs/cancer1/altthrpy.htm#formula

http://www.mnwelldir.org/docs/cancer1/altthrpy2.htm#Escharotics


OUR PERSONAL EXPERIENCES WITH BLACK SALVE

A family member has used the salve four times starting in 1986. He was an alcoholic (now in recovery, 2007) diagnosed with cirrhosis of the liver and wanted to try to salve for his diseased liver--a use we had never heard of. The site advised for use when the diseased area is internal and not near the skin is on the groin, just below the belly and above the center of the leg. The first two times were easy—little pain or discomfort except from bandages and tape and skin that became very sensitive. He could feel the salve pulling from several areas in his body, from the liver area, from his tobacco smoke-damaged lungs, from areas where he had been injured, and especially from several areas of former severe infection from vaccine-caused strept A flesh-eating bacterial infection supposedly “cured” with antibiotics, which never healed properly. However, on the 3rd treatment, he became severely ill, couldn’t keep down food or even tap water (we had to get purified water), and he passed black, tarry matter from the bowels.

We drove 200 miles to a well-known naturopathic physician who determined that it was just a detoxing reaction. She gave him liver protomorphogens (glandular) medicine to support liver function and detoxification. She was right. The illness passed in a few days, and he felt remarkably better afterwards. That was over three years ago and he is just now feeling the need to do the treatment again—probably due to his continued use of harmful substances like tobacco and alcohol.

He does more than the salve treatment to support the healing process. He had “constitutional food intolerances” diagnosed (related to blood type intolerances) by the same naturopathic physician, Dr. Leticia Watrous in Spokane, Washington. (Dr. Joel Wallach, author of best-selling audio tape “ DEAD DOCTORS DON’T LIE” describes how to self-diagnose food allergies in his books-- food allergy testing), and he follows the prescribed diet religiously, as that removes a tremendous source of toxicity and stress to the system. He also follows the general blood type diet suggestions in Dr. D’Adamo’s book “4 diets for 4 blood types.” This has made an extraordinary difference in the family's overall health. Added to that, their diet is primarily raw, except for meat and potatoes, and low carb, which is necessary for improved health in most individuals. At least low in refined carbs, which are dangerous in general.

They also take numerous supplements. Vitamins are present in raw foods because they are created in plant life from sunlight and water. However, the commercial soils of the earth have been long depleted of most of the minerals we need for optimum health. One of the most important is calcium, which is made bio-unavailable when heated, such as in the process of pasteurization, which also makes it more acidic, so milk actually strips more calcium from the body’s resources than it provides. One must supplement minerals or die—it’s that simple, unless you happen to live in one of those small pockets of areas in the world far from civilization where the waters are glacier-fed and food organically grown and people live and work to age 120, as our cells are programmed to do when provided with all the building materials for health.

A short list of most commonly used supplements is available online—they are laboratory-tested and sold for basically non-profit wholesale prices at: ourhealthcoop.com.

Calcium, unless from plant sources like carrots or dark green leafy vegetables, is hard to metabolize and in supplement form may even contribute to deadly arterial plague. A doctor who wrote a book on curing arthritis names calcium supplementation as a necessary part of the treatment, but says it needs certain things to make it bio-available. First—sunlight on the oil-producing areas of the skin for natural vitamin D. No synthetic can possibly replace what sunlight provides. However, he suggests taking a tablespoon of cod liver oil (flavored Norwegian Cod Liver Oil in a little juice) at night. In the morning, a tablespoon of raw, cold-pressed peanut oil (from health food stores). During the day, divide your calcium into 3 or 4 doses, and take it with an acid drink (like citrus fruit juice) to which is added vitamin C crystals or a tablespoonful of apple cider vinegar. (We use lemon juice sweetened with Stevia vegetable sweetener and apple cider vinegar with the "mother", or go right to a honey and vinegar drink.) It is also suggested taking HCL (hydrochloric Acid—stomach/digestive acid) with it, along with pancreatic enzymes and digestive enzymes. But for all of the minerals combined, we use SeaSilver, or something similar like the new "Perfect Food" from Garden of Life, etc. Mainly, get some kind of organically-grown, food-based enzyme rich “SUPER FOOD.” Virtually every health food store in the country carries something referred to as such. They’ll know what you mean immediately.

Some other excellent products are “Km,” a potassium-rich drink made with roots, berries, and the like, created and manufactured in Canada. It's available over the internet. It’s one of the few supplements my family has ever used and seen a visible difference. Thick pads of skin on the bottom of one person's feet softened into normal skin, hair got shinier, and nobody had dental carries for several years after using it. I figure if we could actually see changes, that the unseen changes were there, also. You can order this product from distributors online.

Minerals occur in ratios to each other. The “big 4” are calcium, magnesium, potassium, and sodium. Most people are deficient in some or all of these, along with all the missing trace minerals no longer in the soils that produce our foods. Some people need more calcium in relation to magnesium, or the other way around. The best way to find out for certain what you need or have too much of is to locate some kind of health practitioner (many chiropractors as well as alternative doctors are doing amazing things in the areas of diagnostic work) who can send away a hair sample for mineral analysis. The best-known laboratory in the world of this kind, and its famous doctor/researcher is A.R.L. with Dr. Paul Eck, a pioneer in the field whom most other such diagnostic laboratories and their researchers base their work on.

We also take digestive enzymes after eating (HCL before), and PANCREATIC ENZYMES—a deficiency which many healers consider plays a pivotal role in the development of cancer and other diseases, especially colon cancer.

Avoid HYDROGENATED OILS at all costs. JUST SAY NO!!!!!! We are a world desperately insufficient in our intake of omega 3 & 6 oils, such as from fish oil and flax seed oil, and these manmade oil forms “trick” the oil-starved body into thinking its the “real” thing. They absorb these atrocities into the cells, which glom them up and destroy the cell’s electrical charge which attracts oxygen into the cell. No oxygen=cell death or cell mutation into cancer. Read the work of Dr. Johanna Budwig for the research and the solutions. Any internet search engine will take you to this shocking, life-saving information. We use pure, natural extra-virgin olive oil for cooking and eating (your heart and vascular system love this), and take fish and flaxseed oil for medicine.

The human body must have all 12 cell (tissue) salts which have been long made in homeopathic preparations: Dr. Schussler’s Tissue Salts, found in many health food stores. They come individually, or all 12 in 1, called “BIOPLASMA,” which are healing in themselves. There exists a definitive “Bible” on the subject called “Tissue Salts” or something like that, and it relates all of the symptoms and diseases that can arise from an imbalance or deficiency of any one of these necessary substances.

We use natural glandulars as the need has been diagnosed by healing professionals. My husband has needed liver support and so used the liver “protomorphogens”—the part of the glandular cells that heal them and make them work, and when my adrenals crashed, taking down my thyroid with them and affecting virtually every function and organ in my body, instead of going on synthetic thyroid hormone and suppressing or destroying my own remaining thyroid function, or cortisone, which would both shorten and affect the quality of my life, I used the glandulars, cleansing protocols, and a massive healing effort which eventually restored my health.

Cancer usually involves poor liver function. One needs to go through cleansing and detoxing procedures, particularly designed to restore liver function, since it is the primary agent of filtering and detoxification in your body. The best information and website I’ve found on essential cleansing/detoxing programs is this: http://www.healthfree.com/health/

For additional cleansing and detoxing, we use ESSIAC tea, now available in most health food stores made up or in loose powdered tea form that you make up yourself. Follow the directions carefully, there are specific steps to take in making the tea, which requires an all-day process. Several other famous teas reportedly have similar properties, such as Pau D’Arco tea. Also, mushroom tea (Kombucha tea, as described in the book “Kombucha” by Gunther W. Frank) , which you brew at home with a Kombucha mushroom or starter kit, has a wealth of nutrients and reported healing properties. This is amazing stuff that tastes like a cross between sparkling cider, vinegar, and cheap wine, and gives most people an energy lift immediately. Enervation is a serious condition of low nerve energy that needs to be remedied for any condition of health to be restored.

One simple, natural treatment that has reportedly been used alone successfully as a cancer treatment is the carrot/celery/beet juice mix--raw, fresh vegetables, organically grown if possible. Add selenium, zinc and vitamin E to this mix and you have a healing “elixir.” Whether it’s the calcium, beta-carotene, fresh enzymes, or whatever, these home-juiced vegetables come close to being “miracle” foods. I cheat—the health food store sells powdered carrots and beets which I occasionally substitute, and I admit to going VERY lightly on the beets (they taste gross), but this is the kind of food that makes the best medicine.

Parasites: There exists a large body of documented evidence that parasites play a part in some if not most cancers. How about when they find at the dead center of a tumor a bolus of parasites, dead or otherwise, or find that some excrete toxic substances that trigger malignancy in benign tumors. There are many websites devoted to the subject of parasite treatment, particularly those involving the research of scientist DR HULDA CLARK, who is spite of being infamous and controversial, has impeccable research skills. Most parasite cleanses include the use of green walnut hull, wormwood and cloves—the non-irradiated type you purchase elsewhere than your favorite local grocery store. Also, the remedies of the late HANNA KROGER, whose work and medicines continue to be produced at: 7075 Valmont Rd., Boulder CO 80301.


ONLINE TREATMENT DIRECTIONS (for this site and salve)

The Dan Raber site http://cancerx.org has people who advise those who buy the tumorx salves and other products urged to be used with salves, including bloodroot capsules, minerals, the all-important enzymes which should be taken with all cancer treatments, a supplement that corrects the condition leading to cachexia (wasting) caused by the inability to metabolize proteins from food sources and consuming one's own tissues, etc. Here is an excerpt from his home page:

Primary Products: TumorX Paste, TumorX Capsules, TumorX Tincture, TumorX ATP (Cachexia), TumorX Pancreatic Enzymes And TumorX Plant Enzymes

This is a web site where one can find alternative cancer treatments using anticancer herb ...(Click Here), anticancer enzymes...(Click Here) and nutritional supplements that stop Cachexia Syndrome (Starvation from cancer)...(Click Here). These are used in conjunction to eliminate the cancer from one’s body, to support and rebuild the metabolic processes of the body.

TumorX Paste, Formula Apoptosis, and Formula 203X contains the apoptotic and anti-proliferative ingredient Bloodroot, i.e. Sanguinaria Canadensis L. Bloodroot's anti-cancer compounds have been known historically since the 1750's-1760's as the secret Plunkett family remedy. Benjamin Rush M.D. in the late 1700's, Dr. J. Weldon Fell in the 1850's, Dr. Pattison in the 1860's, Harry Hoxsey’s salve in the 1940's, Dr.Mohs Chemosurgery salve in the 1950's, and Dan Raber's TumorX Paste in the 1990's. All of these people have promoted a paste to kill cancer that used bloodroot as the active ingredient. These pastes have been known historically as black salve, bloodroot salve, other names, and unfortunately as escharotic salves. TumorX Paste is used in conjunction with TumorX Enzymes that can, in most cases, defeat one’s cancers.

Pancreatic Enzymes (TumorX 103X and Formula 303X) have been used in Western medicine dating back to 1900's, then later incorporating plant-based enzymes, i.e. TumorX 403X. Pancreatic enzymes were first researched by Dr. John Beard.in the 1890's. Dan Raber in the 1990's combined Dr. Beards work with the historic bloodroot herb that yielded unprecedented results.

Anyone using salves should purchase Dan's instruction manual and DVD also, as mentioned previously: http://cancerx.org/educational_products.html

http://cancerx.org/bloodroot_directions.html TREATMENT DIRECTIONS


Salve treatment guidence: http://blacksalveinfo.com Rick from the black salve site appears willing to advise anyone using salves from any source, although he has links to salve products. One of the best instruction pages I've seen along with Dan Raber's site, is on the web page at Rick's site: http://blacksalveinfo.com/instrbs.htm TREATMENT INSTRUCTIONS. This is geared more for skin cancers, but the treatment is the same, and he must not realize that deeper cancers can also be treated, as has been our experience.


http://cancersalves.com As stated previously, anyone considering self-treatment with salves would be best advised to purchase the definitive book on cancer salves--different formulas and instructions are included, and to educate yourself on the subject first. Treatment under a licensed medical doctor's care is available in the Philippines. Salve treatment became part of mainstream medicine there after the medical authorities witnessed the safety and effectiveness of this type of cancer protocol.

THE SALVE WE MAKE AT HOME AND USE OURSELVES: (It's much easier and less expensive to buy commercially-made salve in smaller amounts now) One very old formula from a 150-year-old book, with basic instructions (This application is for internal cancers/tumors--for skin cancer the salve would be applied to the whole of the external area in most cases)

ESCHAROTIC SALVES
(Use only enamel or glass pans for making both salves
--no contact with metal)

BLACK SALVEMix together:Black salve application

½ cup of BLOOD ROOT

½ cup of ZINK CHLORIDE

½ cup of WHITE FLOOR

Then gradually stir in:

1 ½ cups WARM WATER

Mix well before putting on to cook in a double boiler.
Cook for ½ hour, stirring often.

LIGHT SALVE---Put in a pan:

1 pint of BOILED LINSEED OIL https://www.youtube.com/watch?v=v2EC1jaD3EA
(Food grade linseed oil or flaxseed oil is
a better alternative, I believe.)

(Get in hardware store or order pharmaceutical grade oil from the cancer salve book.)

Add 1 piece of RESIN the size of a walnut—preferably the green resin used for bass violin. (Get in music store) djt--We found that the bass violin rosen was amber, and the cello rosen was dark green and looks black in the container, so we got the green one.

Add 2½ oz. of BEESWAX and let melt. (DO NOT COOK/BOIL)

Do not have the fire too hot and stir while melting. Take off and cool. Then add:

1 tablespoon of OIL OF SPIKE (I ordered that from the source provided and it said Lavender Oil of Spike-light, but the business appears to be gone now. Many natural food stores carry it or it can be found online--DJT) This appears to be just plain Lavender essentual oil.

 

TREATMENT

On a STERILE WHITE GAUZE put some BLACK SALVE about 1/8th inch thick. Place where you think you have the cancer. Leave this on for 24 hours. If you have cancer, this will turn you a pinkish red and will stick to you. If not, you have no cancer.

(We were advised that people suspecting cancer but not knowing its location could use a general spot below the waist on the left side, under the belt line and above the groin--about half way in between. And the advice to apply salve in about the size of a quarter relates to internal cancers or testing. If the cancer has protruded externally or is a skin cancer, all of the area should be covered. The book Cancer Salves has more specific information for different circumstances.)

If it sticks and turns red, wipe off all of the black salve and clean AROUND the spot with rubbing alcohol. NEVER clean off the spot with alcohol, but only around the spot.
(Hulda Clark, in her book “A Cure For All Cancers” advises to avoid rubbing alcohol because it absorbs internally and provides a chemical that aids in the development of certain dangerous parasites. The salve book suggests using HYDROGEN PEROXIDE.)

Put a good portion of the LIGHT SALVE on and leave for 24 hours. Remove and clean off salve with dry sterile pad. Clean around the spot with alcohol/hydrogen peroxide.

CHANGE THIS EVERY 24 HOURS FOR 6 DAYS. (The person who gave us the salve information suggests changing it every 12 hours instead).

Then again, apply the BLACK SALVE and leave on for 24 hours.

Then back to the LIGHT SALVE, changing every 24 (or 12) hours. An ESCHAR will have formed (pus will form into a large scab-like cap with tiny hair-like filaments--“leaders”--underneath leading off into different directions). CONTINUE USING THE LIGHT SALVE UNTIL THE ESCHAR COMES OUT ON ITS OWN AND THE HEALING IS DONE.

It should come out in 11-13 days from the sixth day; about 17-20 days from the start. When used correctly, very little scarring takes place. NEVER try to force the eschar out. Let it come out of its own accord. Even if it hangs by a small corner, DO NOT try pulling it off.STAY QUIET AS POSSIBLE, especially from the 6th day on. You can walk around a bit, but do not make any sudden moves, as this may break the leaders when the salve is pulling. Best to stay down when it begins to come out. Also, be VERY careful when going to the toilet. You will get very red around the forming scab, but do not get concerned. This is normal. (It gets fiery red in a large area around the scab—do not take anything to suppress what looks like an infection. In fact, inflammation is an important, useful, and necessary function of the immune system in the healing process.)

According to salve expert Dan Raber, the leaders are actually cancerous roots and if they break during treatment instead of absorbing up into the scab and then releasing it, you have to redo the black salve to get it all. http://www.cancerx.org He sells a slightly different formula made up.

DO NOT GET ANY WATER ON THE TREATED AREA. This will stop the action of the salve.

(We have not seen this happen after the process starts and mainly avoid water during the first black salve treatment, but keep it dry the best you can. We try to keep it covered with plastic or something similar to take showers.)

SOURCES

ALL OF THE INGREDIENTS IN SMALL AMOUNTS---http://tinyurl.com/7wre6u6

BLOOD ROOT—sometimes called “Indian Paint” available at some health food stores. You may have to grind it into a powder. (Check internet sources if this isn't available locally. We get ours from herbalcom.com)

ZINK CHLORIDE— Can be found in or through older drug stores or on the internet. (Such as-- http://www.sciencelab.com/page/S/PVAR/10433/SC-Z1060, 500gr., which ended up costing $70+ with hazardous material shipping and UPS special handling fees, but will make several large batches of black salve.)

OIL OF SPIKE (Lavender Oil)—(light kind, not dark) Our original source is gone. They may have moved--check health food stores or do an internet search, but make certain the products aren't irradiated. (Lavender Oil of Spike) We get ours in area health food stores now.


The definitive cancer salve site is Ingrid Naiman's http://cancersalves.com. She has the most comprehensive book available, based on years of research, which contains treatment advice, different salves, their formulas with instructions to make them yourself, and instructions for use. She does NOT advise people personally for legal and time constraint reasons, but her site contains forums to discuss salve use. The book is sold from her site, and is available at online bookstores in hardback, paperback, new and used, but they appear to be far more expensive than what she charges (around $32). This is about escharotic salves, and not all are bloodroot-based, nor contain zinc chloride used in many to assist in a deeper penetration into the tissues. For some cases, she prefers salves with a base of goldenseal, as is explained in the book, and she also has treatment products available on her site, not salves, but such things as the tonic used in the famous Hoxsey treatment, although updated with the replacement of a couple of ingredients with more effective ones.

CANCER SALVES
A Botanical Approach to Treatment (by Ingrid Naiman)

" My book on botanical escharotic treatments of cancer evolved from fairly simple notes based on the experiences of the people who make the products and a few historic sources. Eventually, I found the time to pursue fairly extensive research on the most prominent doctors who used escharotics in their practices, dating back to the 17th century. I also collected dozens of formulae and listened to the stories of many people who used the salves successfully, including medical doctors who used the black and yellow salves on recurrences of their own breast cancers. The introductory section on the history of the salves is followed by a discussion of the various escharotic approaches—there are many—and my own sense as to how and why the salves work as they do. Then, there are some testimonials, some historic, some modern, and a few case histories, again some older and some more recent.
Besides presenting a fairly comprehensive overview of the salves, I address the major frustrations faced by patients who attempt to use the salve without supervision from a health care professional. The primary issue is how to interpret the dramatic changes occurring at the treatment site. To aid patients, I have added color pictures and diagrams. I also offer some suggestions that may reduce the pain and scarring normally accompanying the use of bloodroot pastes.
The book contains material useful to medical herbalists and health care professionals who might want to become more familiar with this treatment. There is a brief discussion of some of the properties of the major herbs used in cancer treatment. There are also nearly 100 recipes, my gift, and hopefully the end of greed surrounding the use of formulae by individuals who considered themselves rather than humanity.

1-888-FAX-HEAL or 360-779-9677"


Salve treatment guidence: http://blacksalveinfo.com Rick from the black salve site appears willing to advise anyone using salves from any source, although he has links to salve products. One of the best instruction pages I've seen along with Dan Raber's site, is on the web page at Rick's site: http://blacksalveinfo.com/instrbs.htm This is geared more for skin cancers, but the treatment is the same, and he must not realize that deeper cancers can also be treated, as has been our experience.

Medical salve use: In the Philippines, medical doctors administer salve treatments as part of their own "orthodox" medical arsenal. Bloodroot salve treatments have been in use since 2002: "Jade Del Mundo Md. From the Department of Health invites you to the Philippines for your healing." (info from the cancerx.org site)

ESCAROTIC CANCER SALVES (bloodroot variety)

(Disclaimer: This material is intended for information only and not given as medical advice, which should come from a licensed health care provider.)

The following formulas for light and dark salves used alternately in an old herbal cancer treatment was submitted to the Yakima Herald-Republic around 1980 by a Yakima Valley chiropractor that promptly lost his license to practice his profession legally because of it.

He reportedly owns a 100+ year old book with this remedy included in it, said to have originated with Canadian Indians, but of which many varieties go way back in time, particularly since the herb bloodroot has been known for it’s tumor-fighting properties since ancient times.

A family friend cut it out and kept it, but we came across information about it from friend of the family who heard about this cancer research project and reported that she had been diagnosed with metasticized breast cancer and sent home from the hospital with instructions to “put her affairs in order” as she was scheduled (by them) to die.

Someone who knew her insisted on giving her the salve treatment. Having nothing to lose, she submitted to the procedure. Later, the same doctors who pronounced the death sentence insisted that it must have been “a misdiagnosis.” No sign of the cancer remained, and she has been cancer-free for many years now.

The above case was mentioned to the former owner of a local health food store. She knew about the salves and someone else who had been using them. The person who used the salve on herself--Bernice Dodd--is the one who gave us the formula in 1996, along with a small container of “black salve”—the first part of this 2-salve (light and black salve) treatment. We made the other one ourselves from the instructions below.

The lady with the breast cancer only used the salve one time but checks every year to see if she gets a positive reaction from it (if left on the skin for a 24 hour period, the black salve will either do nothing or cause a skin reaction, indicating the presence of diseased tissue.)

The family member who has used the treatment several times probably has some cancer or pre-cancerous condition on-going and the treatment keeps it cleaned up. He was also diagnosed with cirrhosis of the liver over 22 years ago, which also seems not to have progressed. In fact, there have been no symptoms of it for many years.

Since this formula was published in our county newspaper, a comprehensive book has been written on the subject of “cancer salves” of which there are many more than the two described here. The author has also created a massive website, so much of this information is available and the book and links to actual prepared formulas which can be purchased are all available online at:

Photo Journal Pages 1  &  2




Dianne Jacobs Thompson  Est. 2003
Also http://legaljustice4john.com
The Misdiagnosis of "Shaken Baby Syndrome" --an unproven theory without scientific support, now in disrepute and wreaking legal and medical havoc world-wide
Author publication: NEXUS MAGAZINE "Seawater--A Safe Blood Plasma Substitute?"

DISCLAIMER: The material on this site is for informational and educational purposes only. Please consult with your health care provider for treatment advice.

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