treatments for cancer, chronic-degerative disease, infection, stress,
harmful emotions and other disorders and conditions;
MGN-3 FOR THE IMMUNE SYSTEM.
MGN-3 for the immune system
A review from the Eclectic Medicine International (EMI) staff at http://www.holisticcancersolutions.com/
JAPANESE BREAKTHROUGH DISCOVERY THAT REVERSES CANCER:
MGN-3 and Cancer
a.Enhances the activity of white blood cells known as natural killer (NK) cells which are considered to be the first line of defense against cancer.
b.Improves immunocompetence to prevent cancer.
c.Combined use with chemotherapy and hormone therapy alleviates side effects of drugs and improves QOL (Quality of Life)
d.Prevents leucopenia caused by chemotherapy and radiotherapy, and minimizes suppression of their efficacies.
e.Promotes leukocyte growth (3 times higher than control group)
Lower blood sugar level in patients with diabetes.
a.Improves immunological parameters in patients with HIV and AIDS.
b.Enhances activity of T cells.
c.Increases Interferon-Gamma production.
d.Ameliorates hepatitis B and hepatitis C ( improvement in GOT, GPT, and Gamma-GPT)
a.For maintenance of health: 600mg/day.
b.For amelioration of diabetes, hepatitis B, and hepatitis C, 1g a day.
c.As an adjuvant for the treatment of patients with Cancer or AIDS; 3g/day for 1 month then 1g/day.
UCLA/DREW University, Department of Urology of Nippon Medical School, Kobe Women College, Jichi Medical School, Kyorin University, Hokkaido University, Teikyo University. 87th Annual Meeting of the American Association for Cancer Research April 20-24,1996 Washington DC NK immunomodulatory function in 27 patients by MGN-3, a modified arabinoxylane from rice bran. Dr. Mamdooh Ghoneum ; Namatalla, Galal. Drew Univ. of Med. & Sci. Dep. Of Otolaryngology, 1621 E. 120th St. Los Angeles, CA 90059 MGN-3 immunomodulatory function was examined in 27 cancer patients.
MGN-3 is an arabinoxylane from rice bran that has been enzymatically modified by hyphomycetes mycelia. The patients had different types of advanced malignancies: 7 patients had breast CA, 7 prostate, 8 multiple myeloma (MM), 3 leukemia and 2 cervical. All patients were under treatment with conventional therapy and were also given 3g of MGN-3 daily, then NK activity was examined at 2 weeks, 3 and 6 months.
Activity of NK cells was examined by 51 Cr-release assay using K562 tumor-cells as targets, at effector: target ratios from 12:1-100:1. Results showed that: 1). Patients had low level of basal NK activity(10.8 - 40%). 2). Treatment with MGN-3 caused a remarkable increase in NK activity at 2 weeks. The percentages of induction were as follows: breast CA 154-332%, prostatic 174-385%, leukemia 100-240%, MM 100-537%, and cervical CA 100-275%. 3). Enhancement of NK activity continue to rise at 3 and 6 months after treatment. MGN-3 was offered by Daiwa Pharm. Co., Ltd. Tokyo Japan. Results of this study demonstrated that: 1) Majority of cancer patients had low basal NK cell activity (figures 1-6). 2) Treatment with MGN-3 resulted in significant increase in NK activity as early as 2 weeks post treatment (figures 1-6). 3)
Further increase in NK activity was observed at 3 and 6 months. 4) The mechanism by which MGN-3 augments NK activity through increasing NK cell granularity. We conclude that MGN-3 is a potent Biological Response Modifier (BRM) as manifested by highly increase in human NK cell activity at 2 weeks post treatment. The induction of NK activity by MGN-3 may represent a new immune-therapeutic approach for the treatment of cancer which needs to be examined in multiple clinical trials.
Good News For Cancer Patients MGN-3 is quite possibly the most powerful immune booster known until today. Also effective for Pre-cancerous Cells, HIV and Hepatitis. Additional therapeutic and preventive applications for MGN-3: heavy smokers, heavy drinkers, individuals who constantly work with paint (artists, house painters, etc), individuals born with immune deficiencies, families with a strong history of cancer, chemical and refinery workers. Lane Labs Inc., a leader in the development of efficacy-based natural products, announces the introduction of MGN-3, a breakthrough in the field of immune defense and assisting the body's immune system to achieve ultimate defensive productivity.
MGN-3, a patented extract from the outer shell of rice bran, integrates enzymes from three medicinal mushrooms, resulting in a 300% increase in the proliferation of Natural Killer (LTK) Cells, the body's first line defense. B-Cell & T-Cell activity is also increased by 250% and 200% respectively, giving the immune system a fighting chance to attain the ultimate protection. "This product has been in the development phase for the past 10 years," stated Andrew J. Lane, president of NJ-based Lane Labs which maintains the exclusive rights to market the product worldwide. "This is truly a revolutionary breakthrough," Lane continued. "MGN3 has been rigorously tested and studied resulting in a non-toxic supplement that can be used for special benefits or as a general preventive health supplement that augments the immune system." "After all, who wouldn't want to have the body's defenses tripled," Lane concluded. With 7 independent published U.S. studies (72 human patients) to support the product's claims, MGN3 is bound to have an immediate impact on the immune stimulation industry. "I have been researching mushrooms and NK-Cell activity for over 16 years," added Mamdooh Ghoneum, Chief of Research for the Dept. of Immunology at Drew University of Medicine & Science. " MGN3 is the most powerful immune complex that I have ever tested." Lane Labs is among the world's premier suppliers of specialty natural products for chronic disease. The company, which dedicates more than 10% of its annual revenue to fund research and development endeavors for solutions to Cancer, HIV, Hepatitis and Diabetes etc., is presently sponsoring three FDA Phase 11 clinical trials at the Hackensack (NJ) University Medial Center, and Northwestern University Medical Center in Chicago. MGN-3 combines the latest in traditional (holistic) medicine with conventional thinking, resulting in a product with a unique molecular structure that allows for easy systemic absorption with the highest possible results. MGN-3 Natural Immune Enhancing Complex, is the result of many years of diligent research lead by Dr. Mamdooh Ghoneum. The research conducted by Dr. Ghoneum at UCLA and Drew University has lead to the creation of the most advanced protection for your immune system. (Dr. Ghoneum's work with MGN-3 began in Japan.) MGN-3 is a derivative from the outer shell of rice bran that has been enzymatically integrated with extract from the medicinal mushroom "Hyphomycetes Mycelia" (Shitake). This formulation is proven to triple Natural Killer (NK) Cell activity and in some cases increase NK Cell activity up to seven times their normal level. As you probably know, Natural Killer Cells act as the first line of defense for any type of invasion in the body. The secret to the effectiveness of MGN-3 is in the integration of rice bran with mushroom extract. It is this patented formula that increases the body's ability to absorb more of the immune enhancing properties. Most importantly, unlike other "Immune stimulators", MGN-3 has human clinical data to substantiate the level of NK Cell activity. INTERVIEW WITH DR. MAMDOOH GHONEUM -- 7/15/97 Department of Immunology, Drew University of Medicine and Science Q. Dr. Ghoneum, how long have you been researching MGN-3 ? A. I have been studying MGN-3 almost seven years now. Q. And tell me a little about your background. A. I am an immunologist and have been working in the field of immunology since I started my Masters in 1973. Q. What exactly is MGN-3? A. MGN-3 is a natural product, isolated from the outer shell of rice bran. This rice bran has been shown to be very effective and have chemical anti-viral effects and we have known about it for 20 years. What is important here is that we have slightly modified the rice bran base and the resulting immunological effects of this product have become extremely high. Q. What is it's effect on the body? A. This product causes overall stimulation of the immune system, like T-cell function, B-cell function, and in particular, which has been most of my research in the last ten years, the production of natural killer activity. And when we talk about cancer, we have to mention the natural killer cells, because these cells, which constitute about 50% of your white blood cells, have been defined as the first line of defense against cancer and virally infected cells. These NK cells were discovered at least 50 years ago and attracted the interest of many scientists all over the world. Last year alone, over 2 thousand doctors were published in this regard around the world. Q. In your opinion, is there anything available on the market today, whether by prescription or not, that is in any way comparable to your MGN-3? A. Well, I think the problem with most of the products on the market in general is that they have not been examined scientifically in a laboratory. They have great publicity and marketing people behind them and are heavily advertised by the media, so the public believes they are effective. When in actuality, there are no peer-reviewed articles attached to most of these products that have been presented in any scientific Journals of any kind. And if there have been some studies, they have been in-vitro studies or animal studies, which do not prove, necessarily, an applicability to humans. Q. What are the major advantages in the use of MGN-3? A. The advantages to MGN-3 are many. One is that it is a natural product, as I mentioned earlier. It has no immutable side effects. Liver and kidney function are examined and blood tests are done prior to the patient's taking the product and then several months after beginning treatment, and there have been no changes in the blood enzyme levels. So we know this is a very safe product. This cannot be said about most medications designed to boost the immune system, like Interferon or Interieukin 2 for example, which have severe side effects ranging from nausea and vomiting to kidney failure. There have been many patients who have died from the kidney failure, not the cancer. So you can see that the side effects of Cytokines like these are enormous, and these are the ones which have been designed to boost the immune system. MGN-3 is a biological response modifier or BRM, which is the definition that we use to define any material entering your body that boosts the immune system, that does not cause any toxic side effects and is completely safe. This is a real break-through in the area of immunology. Q. How is MGN-3 prescribed and in what form? A. It comes in both tablets and powder. Four tablets are equal to 1 gram and the initial booster dosage is 3 grams, 4 tablets three times a day, for 2 weeks. Then I gram or 4 tablets a day thereafter on a maintenance program. Q. What about vitamin supplementation in addition to the MGN-'3? A. I don't think there is a clear study connecting the use of vitamins in the treatment of cancer. There have been hundreds of articles written specifically about vitamin C and there is a lot of controversy about this vitamin and its effect on the immune system. In fact, we have found that 60 % of patients taking vitamin C may have some benefit from taking it, whereas 40% show no effect on their immune system and, in some cases, even lowered immune functions. More importantly, there have been 6 major articles published showing that high doses of vitamin C caused the enlargement of cancer and procreation of the tumor. Q. Between early stage cancer patients who have and have not been exposed to adjuvant therapy like chemo and radiation, which of them will see faster results from the MGN-3? A. For those who have had surgery and then been exposed for only a short time to chemotherapy or radiation, the MGN-3 will boost the natural killer cell activity so that they can destroy whatever small amount of cells that escaped the surgeon or those treatments. Q. What about a stage I patient who comes to you after having surgery, who has no metastases and no adjuvant treatment? A. Patients deserve the chance to be given the opportunity to boost their immune systems with MGN-3 therapy before being given chemotherapy or radiation. Q. Have you done research with MGN-3 on patients with HIV or AIDS? A. In-vitro studies have shown beautiful results with MGN-3 and its effect on other viruses, including the HIV virus. Our research patients on MGN-3 have shown dramatic increase in T cells, some of them showing a decrease in viral load as well. Q. Is your product available anywhere in the world to the general public? A. It has been available in Japan for the last 7 years, where it is manufactured, and some other eastern countries like Korea. And now it is in the process of being introduced to Thailand, Malaysia, the Philippines, several European countries and in Brazil. Q. I understand that you are considered a "hero" in Japan. A. Yes, I have published 10 books about MGN-3 in Japanese and they know this product very well there. There are several thousand cancer patients taking this treatment in Japan. Q. How have you found the effects of stress to play an important part when a patient is taking the MGN-3? A. We examined the effects of stress using brain as model and we were able to make a very interesting observation that during a stressful condition, natural killer cells migrate back to the sight where they came from, which is bone marrow. Of course, that lowers the immune function. In addition to other side effects where brain messengers suppress the immune suppression. I think the problem here is very individual. What is stressful for one may not be stressful to another. A lot of stress, whether it be work related, at home, with family members, or due to financial problems or loss of a loved one, always suppresses immune function and can therefore be a major cause in developing cancer and other diseases as well. Q. Does any particular cancer respond better to the MGN-3 than another? A. Yes. Cancers of the blood like leukemia and multiple myeloma have shown great response to this treatment. These patients' immune systems have boosted very easily because the natural killer cells can reach their target, the cancer cells, in the bloodstream much more easily. When you have solid tumors, the NK cells have to penetrate the inside of the tumor tissue and destroy the cancer. In order to do that they have to go through many mine fields and explosions because the cancer has to protect itself inside the tumor milieu, so there are quite a lot of immune suppressive factors created by the cancer cells to protect itself and destroy the immune system before it can destroy the cancer. Still, we have had great results with these types of cancer as well, such as ovarian, prostate and breast cancer. Q. What has your success rate been with the many patients that have been in your research program over the last 7 years? A. Our success rate with MGN-3 has been excellent. Except for the patients who were so terminal, with cancer having spread all over their body, all of the other patients have shown dramatic results. Q. Would you say that those who were terminal, the MGN-'3 was able to extend their lives beyond what their doctors would have expected? A. Absolutely. Where their doctor sentenced them to one or two months, we were about to give them a year or a year and a half. Q. How important do you think diet, exercise and lifestyle are to the success of your program with MGN-3? A. The first thing a cancer patient or immune suppressed patient must realize is that no matter how gifted the surgeon, immunologist, oncologist or other health practitioner may be, and no matter how effective their treatment may be at eliminating the problem, nothing and no one can eliminate this serious problem I00% unless the patient is willing to make the necessary changes in their life to correct the underlying problem that brought them to their present condition, whether it be their stress level, their diet, or general lifestyle. They need to remember that it took more than 15 or 20 years for the cancer to develop in the body and it will require a great effort to eliminate it. The patient has to take more then a little responsibility in the healing process. They must have a healthy diet that includes at least 5 servings of different fresh vegetables and fruits every day. They need to work on stress management and reduction using yoga, meditation, mind-body connection therapy, etc. If your job is extremely stressful, maybe you should have to change it. If patients continue to be very stressed, their immune system cannot be boosted and no amount of any product or treatment is going to help them, Another is the need for regular, moderate exercise, this is also very important. Your doctor cannot be with you 24 hours a day to monitor your lifestyle, you have to do it for yourself. Dr. Ghoneum's articles and abstracts on MGN-3 are scheduled to be published in several major medical journals worldwide later this year. Answers To the Most Important Questions about MGN-3 By I. William Lane, Ph.D. What Is MGN-3? MGN-3 is a natural supplement that human clinical studies have proven can more than triple Natural Killer (NK) cell activity and enhance B and T cell function better than any other vitamin, herbal or medicinal mushroom therapies tested. What makes MGN-3 revolutionary is that its effects are similar to pharmaceutical immune stimulants, such as synthetic Interleukin-2 (IL-2), without the toxic side-effects. MGN-3 (Arabinoxylane compound) is composed of the hemicellulose-B extract from the outer shell of rice bran, enzymatically modified through a patented process with polysaccharides from medicinal mushrooms (Hyphomycetes Mycelia). Published, peer review research proving MGN-3's beneficial effects include in vitro and in vivo studies and data from 72 human patients. Natural Killer (NK) cells are considered to be the body's first line of defense against disease. Studies specifically on patients battling cancer, HIV, and hepatitis show that MGN-3 empowers NK cells to kill more disease cells, resulting in improvement in clinical status. Research also shows that MGN-3 improves the overall immune system function, which benefits for both healthy and sick individuals - and has proven to be safe and nontoxic, responses. Dr. Lane, why did you become interested in MGN-3? The man behind MGN-3 is an internationally recognized immunologist, Mamdooh Ghoneum, Ph.D., an expert in the field of cancer immune therapy using biological response modifiers (BRMS) to activate NK cells that kill and eliminate cancer cells. Dr. Ghoneum earned his Ph.D. in radioimmunology at the University of Tokyo, and did post-graduate work in cellular and molecular immunology at the UCLA School of Medicine. He has published over 130 articles and abstracts and is presently an Associate Professor and the Chief of Research in the Department of Immunology at Charles D. Drew University of Medicine and Science, in Los Angeles, and an Associate Professor in the Department of Neurobiology at the UCLA School of Medicine. Dr. Ghoneum has said that MGN-3 is, "the most powerful immune complex I have ever tested". His research was buried in the peer review journals until now. I will be publishing a book on the immune system and natural therapies late in 1999, and hope to bring facts on MGNT-3 to the attention of the general public, How does boosting the immune system by activating NK cells improve health? The immune system is the body's defense mechanism against infection, disease and all forms of invaders. It is comprised of more then 130 types of white blood cells (leukocytes & lymphocytes), each of which fulfills specific functions in the cascade of immune system responses. Oral supplementation with MGN-3 his been shown to increase the body's production of natural cytokynes including interleukin-2, interferon and tumor necrosis factors. These cytokynes can directly inhibit replication of viruses and have anticancer effects. Cytokynes also tell the immune system cells to "turn on" -which boosts B cell and T cell proliferation and activity, and causes an increase in granule formation within Natural Killer (NK) cells. The granules within NK cells can be considered NK cell "ammunition," and the greater the number of granules in a given NK cell, the greater its ability to bind with and kill disease cells. Natural Killer (NK) cells are considered the "elite troops" of the immune system, the first line of defense, because they can act on their own rather than strictly in concert with other white blood cells. NK cells make up approximately 15% of white blood cells, but it is not the number or "count" of NK cells that matters, but rather the activity or "function" of NK cells that determines who gets sick and who stays healthy. Research shows that individuals with low functioning NK cells are more susceptible to immune disfunction, viral infection and cancer. Can you summarize the proof of MGN-3's effectiveness? To date there are some 7 published human studies with over 72 patients involved. The results are astonishing. MGN-3 is proven to enhance NK cell activity by more than 300% and increase the activity of B cells by 250% or greater and T cells by 200%. A study with 24 patients showed that MGN-3 effected NK cell activity over time, in a dose dependent manner. Results using 3 gram per day of MGN-3 orally showed NK activity increased by 8 times within one week and that by 2 months, NK cells were killing 27 times (2,700%) more cancer cells than without MGN-3 supplementation. No side effects were reported, and after stopping MGN-3, NK cell activity returned to baseline within one month (Int. J. Immunotherapy 98;XJV (2):89-99) In 27 cancer patients (7 breast, 7 prostate, 9 multiple myeloma, 3 leukemia, 2 cervical) with low baseline (before treatment) levels of NK activity, improvements were measured as early as two weeks which continued to build at 3 and 6 months. At two weeks increases in NK activity by cancer type were as follows: breast 134% to 332%, prostate 174% to 385%, multiple myeloma 100% to 537%, leukemia 1000/o to 240%, and cervical 100% to 275%. (Abstract 87'h Annual Meeting of the American Association of Cancer Research, Washington, DC. April 22-24, 1996) A study involving 5 breast cancer patients using 3 grams per day of MGN-3 orally for 6 to 9 months showed increases in NY, activity of between 26% and 425%. Higher NK activity was detected as early as 1 to 2 weeks post-treatment, and at the end of the study two patients were in complete remission. (Abstract American Assoc. For Cancer Research (AACP,), Special Conference, Baltimore, NO. November 5-8, 1995) During the progression of AIDS NK call activity drops. In vitro research showed MGN-3 antiviral effects and inhibited HIV replication without cytotoxicity in a dose dependent manner. (Abstract XI International Conference on AIDS, Vancouver, BC, Canada. July 7-12, 1996. Biochemical & Biophysical Research Communications, 243, 2 -29, 1998) Who can benefit from MGN-3? It can be used successfully as a sole therapy, an adjunct therapy, or as a supplement to prevent disease and maintain good health. Research has focused on patients with cancer, HIV and hepatitis, so anyone with a personal or family history of these diseases should consider using MGN-3. Dr. Ghoneum has "high risk" categories of people that he believes should use MGN-3 as a form of disease prevention including smokers, heavy drinkers, individuals who work with chemicals (painters/artists, chemists, refinery workers, etc), individuals with immune deficiencies, those with a personal or family history of cancer. What are the MGN-3 dosage recommendations? As a supplement to maintain good health Dr, Ghoneum believes 2 capsules daily is sufficient. For the treatment of disease he recommends a loading dose of 3 grams (twelve 250 mg capsules) per day with meals (4 capsules with breakfast, lunch and dinner) for the first two weeks and a maintenance dose of 1 gram (4 capsules) daily thereafter. Because MGN-3 shows a dose response, higher doses increase immune function higher, faster, and because MGN-3 has been shown to be safe to use for long periods of time, Dr. Ghoneum believes it makes sense for seriously ill individuals to stay on the high dose longer (until they see a drop in their blood markers, tumor shrinkage, or other signs of clinical improvement). For children, adjust dosage to reflect patient body weight. At the loading dose take 45 mg of MGN-3 per kilo of patient body weight daily, and at the maintenance dose take 15 mg of MGN-3 per kilo of patient body weight, Can MGN-3 be combined with other therapies? Using MGN-3 for the treatment of disease is a matter that should be discussed with your doctors. Research shows that because of its method of action and lack of side effects, it will not interfere with most other conventional and alternative therapies. More likely, therapies that depress the immune system will interfere with MGN-3. Dr. Ghoneum cautions that because many prescription drugs and alternative therapies have not been researched for their effects on Natural Killer (NK) cell function, he suggests discontinuing any non-essential prescription medications and therapies while using MGN-3 How do MGN-3's effects compare to the effects on NK cells of other natural supplements? Natural therapies that have been used in folk medicine for centuries are popular today, but most lack data on use in humans to back their claims. Of all the herbal, vitamin or mushroom therapies that claim to enhance NK cell function, only MGN-3 has significant data from studies in humans to prove its effects. In studies done in mice, the best data available, inositol (IP-6) increased NK cell activity by 40%, studies with maitake mushrooms showed a 50% increase, MGN-3 shows a greater affect, increasing NK cell activity by more than 200%, and has better data because it comes from studies in humans, not mice. * * * * * This remarkable Biological Response Modifier substance is one of the great gifts to humanity from the research of holistic medical scientists. While mainstream science is waging its losing war against cancer, so-called 'unapproved' medicine is quietly winning it. We urge you to take full advantage of the information given on these pages."
The exclusive world wide rights to market MGN-3 belongs to Lane Laboratories. The information provided here is excerpts from Lane Laboratories' online brochure.
NAME OF TREATMENT:
Dianne Jacobs Thompson Est. 2003
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